Dr. Heidi Noels and Dr. Yvonne Döring receive the W.H. Hauss Award from the DGAF
19-21 April 2018
Dr. Heidi Noels from the Institute for Molecular Cardiovascular Research at RWTH Aachen University together with Dr. Yvonne Döring from the Institute for Prophylaxis and Epidemiology of Circulatory Diseases at LMU Munich together received the DGAF W.H. Hauss Award 2018 from the German Society for Atherosclerosis Research (DGAF) during the 32nd Annual Meeting of the DGAF in Rauischholzhausen, Germany. They were awarded for their publication "Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies." (Circulation. 2017; 136: 388-403). In this work it could be shown that vascular CXCR4 has an atheroprotective function by maintaining the arterial integrity and preserving the endothelial barrier function. In addition, CXCR4 stabilizes a contractile smooth muscle cell phenotype. Targeted enhancement of these CXCR4-mediated protective functions could open up novel therapeutic options in the treatment of atherosclerosis.
The award was sponsored by a long-standing active member of the DGAF, Prof. Dr. Winfried März.
Project area Z
Administrative project
Robert Werner Mertens
MD student
University Hospital RWTH Aachen
Department of Internal Medicine
Project: The role of incretin hormone GLP-2 in septic cardiomyopathy
PI: Michael Lehrke
Robert Werner Mertens
MD student
University Hospital RWTH Aachen
Department of Internal Medicine
Project: The role of incretin hormone GLP-2 in septic cardiomyopathy
PI: Michael Lehrke
Consortium
Mechanisms of Cardiovascular Complications
in Chronic Kidney Disease
The SFB/TRR219 is supported by the German Research Foundation (DFG)
Project-ID 322900939
2021
Benedikt Linz, Mathias Hohl, Lisa Lang, Dickson W L Wong, Alexander G Nickel, Carolina De La Torre, Carsten Sticht, Klaus Wirth, Peter Boor, Christoph Maack, Thimoteus Speer, Thomas Jespersen, Ulrich Schotten, Prashanthan Sanders, Michael Böhm, Dominik Linz
Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model
Heart Rhythm (2021)
Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Paton J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamari JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R.
Decoding myofibroblast origins in human kidney fibrosis.
Nature (2021)
Speer T, Ridker PM, von Eckardstein A, Schunk SJ, Fliser D.
Lipoproteins in chronic kidney disease – from bench to bedside.
European Heart Journal (2021)
2020
Claudia Goettsch, Agnieszka Strzelecka-Kiliszek, Laurence Bessueille, Thibaut Quillard, Laura Mechtouff, Slawomir Pikula, Emmanuelle Canet-Soulas, Jose Luis Millan, Caroline Fonta, and David Magne
TNAP as a therapeutic target for cardiovascular calcification: a discussion of its pleiotropic functions in the body
Cardiovascular Research (2020)
Marina A. Heuschkel, Nikolaos T. Skenteris, Joshua D. Hutcheson, Dewy D. van der Valk, Juliane Bremer, Philip Goody, Jesper Hjortnaes, Felix Jansen, Carlijn V.C. Bouten, Antoon van den Bogaerdt, Ljubica Matic, Nikolaus Marx and Claudia Goettsch
Integrative Multi-Omics Analysis in Calcific Aortic Valve Disease Reveals a Link to the Formation of Amyloid-Like Deposits
Cells (2020)
Stefan J Schunk, Thimoteus Speer, Ioannis Petrakis, Danilo Fliser
Dickkopf 3-a novel biomarker of the 'kidney injury continuum'
Nephrology Dialysis Transplantation (2020)
Stephen Zewinger, Jochen Reiser, Vera Jankowski, Dalia Alansary, Eunsil Hahm, Sarah Triem, Mira Klug, Stefan J Schunk, David Schmit, Rafael Kramann, Christina Korbel, Emmanuel Ampofo, Matthias W Laschke, Simina-Ramona Selejan, Anna Paschen, Tobias Herter, Susanne Schuster, Gunther Silbernagel, Martina Sester, Urban Sester, Gunter Assmann, Robert Bals, Gerhard Kostner, Willi Jahnen-Dechent, Michael D Menger, Lucia Rohrer, Winfried Marz, Michael Bohm, Joachim Jankowski, Manfred Kopf, Eicke Latz, Barbara A Niemeyer, Danilo Fliser, Ulrich Laufs, Thimoteus Speer
Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation
Nature Immunology (2020)
Marieke Sternkopf, Magdolna Nagy, Constance C F M J Baaten, Marijke J E Kuijpers, Bibian M E Tullemans, Julia Wirth, Wendy Theelen, Tom G Mastenbroek, Michael Lehrke, Benjamin Winnerling, Lesley Baerts, Nikolaus Marx, Ingrid De Meester, Yvonne Doring, Judith M E M Cosemans, Andreas Daiber, Sebastian Steven, Joachim Jankowski, Johan W M Heemskerk, Heidi Noels
Native, Intact Glucagon-Like Peptide 1 Is a Natural Suppressor of Thrombus Growth Under Physiological Flow Conditions
Arteriosclerosis, Thrombosis, and Vascular Biology (2020)
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Heidi Noels, Joachim Jankowski
Editorial on the Special Issue "Comorbidities in Chronic Kidney Disease"
Toxins (2020)
Julia Moellmann, Barbara M Klinkhammer, Patrick Droste, Ben Kappel, Elias Haj-Yehia, Sebastian Maxeiner, Anna Artati, Jerzy Adamski, Peter Boor, Katharina Schutt, Gary D Lopaschuk, Subodh Verma, Nikolaus Marx, Michael Lehrke
Empagliflozin improves left ventricular diastolic function of db/db mice
Biochimica et Biophysica Acta - Molecular Basis of Disease (2020)
Bilal Mir, Claudia Goettsch
Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo
Cells (2020)
Benedikt Linz, Mathias Hohl, Ricardo Mishima, Arnela Saljic, Dennis H. Lau,
Thomas Jespersen, Ulrich Schotten, Prashanthan Sanders, Dominik Linz
Pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut reduces atrial fibrillation susceptibility in obese spontaneously hypertensive rats
IJC Heart & Vasculature (2020)
Florian Kahles, Marcia V Ruckbeil, Robert W Mertens, Ann C Foldenauer, Maria C Arrivas, Julia Moellmann, Corinna Lebherz, Moritz Biener, Evangelos Giannitsis, Hugo A Katus, Nikolaus Marx, Michael Lehrke
Glucagon-like peptide 1 levels predict cardiovascular risk in patients with acute myocardial infarction
European Heart Journal (2020)
Nadine Kaesler, Anne Babler, Jurgen Floege, Rafael Kramann
Cardiac Remodeling in Chronic Kidney Disease
Toxins (2020)
Jana Holmar, Heidi Noels, Michael Bohm, Shruti Bhargava, Joachim Jankowski, Setareh Orth-Alampour
Development, establishment and validation of in vitro and ex vivo assays of vascular calcification
Biochemical and Biophysical Research Communications (2020)
Jana Holmar, Sofia de la Puente-Secades, Jürgen Floege, Heidi Noels, Joachim Jankowski and Setareh Orth-Alampour
Uremic Toxins Affecting Cardiovascular Calcification: A Systematic Review
Cells (2020)
Mathias Hohl, Manuel Mayr, Lisa Lang, Alexander G. Nickel , Javier Barallobre-Barreiro, Xiaoke Yin ,Thimoteus Speer, Simina-Ramona Selejan, Claudia Goettsch, Katharina Erb, Claudia Fecher-Trost, Jan-Christian Reil, Benedikt Linz, Sven Ruf, Thomas Hübschle, Christoph Maack, Michael Böhm, Thorsten Sadowski, Dominik Linz
Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice
JBC Journal (2020)
Anika Himmelsbach, Carina Ciliox, Claudia Goettsch
Cardiovascular Calcification in Chronic Kidney Disease-Therapeutic Opportunities
Toxins (2020)
Marietta Herrmann, Anne Babler, Irina Moshkova, Felix Gremse, Fabian Kiessling, Ulrike Kusebauch, Valentin Nelea, Rafael Kramann, Robert L Moritz, Marc D Mckee, Willi Jahnen-Dechent
Lumenal calcification and microvasculopathy in fetuin-A-deficient mice lead to multiple organ morbidity
PLoS One (2020)
Juliane Hermann, Heidi Noels, Wendy Theelen, Michaela Lellig, Setareh Orth-Alampour, Peter Boor, Vera Jankowski, Joachim Jankowski
Sample preparation of formalin-fixed paraffin-embedded tissue sections for MALDI-mass spectrometry imaging
Analytical and Bioanalytical Chemistry (2020)
Francesco Giorgino, Irene Caruso, Julia Moellmann, Michael Lehrke
Differential indication for SGLT-2 inhibitors versus GLP-1 receptor agonists in patients with established atherosclerotic heart disease or at risk for congestive heart failure
Metabolism (2020)
Michael Böhm, Kazuomi Kario, David E Kandzari, Felix Mahfoud, Michael A Weber, Roland E Schmieder, Konstantinos Tsioufis, Stuart Pocock, Dimitris Konstantinidis, James W Choi, Cara East, David P Lee, Adrian Ma, Sebastian Ewen, Debbie L Cohen, Robert Wilensky, Chandan M Devireddy, Janice Lea, Axel Schmid, Joachim Weil, Tolga Agdirlioglu, Denise Reedus, Brian K Jefferson, David Reyes, Richard D’Souza, Andrew S P Sharp, Faisal Sharif, Martin Fahy, Vanessa DeBruin, Sidney A Cohen, Sandeep Brar, Raymond R Townsend, on behalf of the SPYRAL HTN-OFF MED Pivotal Investigators
Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial
The Lancet (2020)
Martin Berger, Marcus E Kleber, Graciela E Delgado, Winfred Marz, Meinitzer Andreas, Peter Hellstern, Nikolaus Marx, Katharina A Schuett
Trimethylamine N-Oxide and Adenosine Diphosphate-Induced Platelet Reactivity Are Independent Risk Factors for Cardiovascular and All-Cause Mortality
Circulation Research (2020)
Anne Babler, Carlo Schmitz, Andrea Buescher, Marietta Herrmann, Felix Gremse, Theo Gorgels, Juergen Floege, Willi Jahnen-Dechent
Microvasculopathy and soft tissue calcification in mice are governed by fetuin-A, magnesium and pyrophosphate
PLoS One (2020)
2019
Albert J. Omlor, Franziska C. Trudzinski, Mohamad Alqudrah, Frederik Seiler, Frank Biertz, Claus F. Vogelmeier, Tobias Welte, Henrik Watz, Benjamin Waschki, Titus J. Brinker, Stefan Andreas, Sebastian Fähndrich, Peter Alter, Rudolf A. Jörres, Michael Böhm, Robert Bals on behalf of German COSYCONET Cohort
Time‑updated resting heart rate predicts mortality in patients with COPD.
Clinical Research in Cardiology (2019)
Van Roeyen CRC, Martin IV, Drescher A, Schuett KA, Hermert D, Raffetseder U, Otten S, Buhl EM, Braun GS, Kuppe C, Liehn E, Boor P, Weiskirchen R, Eriksson U, Gross O, Eitner F, Floege J, Ostendorf T.
Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension.
Kidney International (2019)
Michael Böhm, Jonathan Slawik, Martina Brueckmann, Michaela Mattheus, Jyothis T. George, Anne Pernille Ofstad, Silvio E. Inzucchi, David Fitchett, Stefan D. Anker, Nikolaus Marx, Christoph Wanner, Bernard Zinman and Subodh Verma
Efficacy of empagliflozin on heart failure and renal outcomes in patients with atrial fibrillation: data from the EMPA-REG OUTCOME trial.
European Journal of Heart Failure (2019)
Schumacher D, Alampour-Rajabi S, Ponomariov V, Curaj A, Wu Z, Staudt M, Rusu M, Jankowski V, Marx N, Jankowski J, Brandenburg V, Liehn EA, Schuh A
Cardiac FGF23: new insights into the role and function of FGF23 after acute myocardial infarction.
Cardiovascular Pathology (2019)
Gajjala PR, Bruck H, Noels H, Heinze G, Ceccarelli F, Kribben A, Saez-Rodriguez J, Marx N, Zidek W, Jankowski J, Jankowski V
Novel plasma peptide markers involved in the pathology of CKD identified using mass spectrometric approach.
Journal of Molecular Medicine (2019)
Sean S. Scholz, Markus Dillmann, Alexander Flohr, Christina Backes, Tobias Fehlmann, Dominic Millenaar, Christian Ukena, Michael Böhm, Andreas Keller, Felix Mahfoud
Contemporary scientometric analyses using a novel web application: the science performance evaluation (SciPE) approach.
Clinical Research in Cardiology (2019)
Sean S. Scholz, Lucas Lauder, Sebastian Ewen, Kulenthiran Saarraaken, Nikolaus Marx, Orazbek Sakhov, Floris Kauer, Adam Witkowski, Marco Vaglimigli, William Wijns, Bruno Scheller, Michael Böhm, Felix Mahfoud
One‑year clinical outcomes in patients with renal insufficiency after contemporary PCI: data from a multicenter registry.
Clinical Research in Cardiology (2019)
Sean S. Scholz, MD; Davor Vukadinović, MD; Lucas Lauder, MD; Sebastian Ewen, MD; Christian Ukena, MD; Raymond R. Townsend, MD; Stefan Wagenpfeil, PhD; Michael B€ohm, MD; Felix Mahfoud, MD
Effects of Arteriovenous Fistula on Blood Pressure in Patients With End-Stage Renal Disease:
A Systematic Meta-Analysis.
Journal of the American Heart Association (2019)
Jonathan Slawik, Lucas Adrian, Mathias Hohl, Sarah Lothschütz, Ulrich Laufs and Michael Böhm
Irregular pacing of ventricular cardiomyocytes induces pro-fibrotic signalling involving paracrine effects of transforming growth factor beta and connective tissue growth factor.
European Journal of Heart Failure (2019)
Christian Ukena, Tobias Seidel, Konstantinos Rizas, Davide Scarsi, Dominic Millenaar, Sebastian Ewen, Axel Bauer, Felix Mahfoud, Michael Böhm
Effects of renal denervation on 24‑h heart rate and heart rate variability in resistant hypertension.
Clinical Research in Cardiology (2019)
Davor Vukadinović, Sean S. Scholz, Franz H. Messerli, Michael A. Weber, Bryan Williams, Michael Böhm and Felix Mahfoud
Peripheral edema and headache associated with amlodipine treatment: a meta-analysis of randomized, placebo-controlled trials.
Journal of Hypertension (2019)
Christian M. Werner, Anne Hecksteden, Arne Morsch, Joachim Zundler, Melissa Wegmann, Jurgen Kratzsch, Joachim Thiery, Mathias Hohl, Jörg Thomas Bittenbring, Frank Neumann, Michael Böhm, Tim Meyer and Ulrich Laufs
Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study.
European Heart Journal (2019)
Qinxue Sun, Maike Baues, Barbara M Klinkhammer, Josef Ehling, Sonja Djudjaj, Natascha I Drude, Christoph Daniel, Kerstin Amann, Rafael Kramann, Hyojin Kim, Julio Saez-Rodriguez, Ralf Weiskirchen, David C Onthank, Rene M Botnar, Fabian Kiessling, Jurgen Floege, Twan Lammers, Peter Boor
Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis
Science Translational Medicine (2019)
Marieke Sternkopf, Sven Thoroe-Boveleth, Tobias Beck, Kirsten Oleschko, Ansgar Erlenkotter, Ulrich Tschulena, Sonja Steppan, Thimoteus Speer, Claudia Goettsch, Vera Jankowski, Joachim Jankowski, Heidi Noels, Eutox European Uremic Toxin Work Group
A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients
Toxins (2019)
Stefan J Schunk, Alexander Zarbock, Melanie Meersch, Mira Kullmar, John A Kellum, David Schmit, Martina Wagner, Sarah Triem, Stefan Wagenpfeil, Hermann-Josef Grone, Hans-Joachim Schafers, Danilo Fliser, Thimoteus Speer, Stephen Zewinger
Association between urinary dickkopf-3, acute kidney injury, and subsequent loss of kidney function in patients undergoing cardiac surgery: an observational cohort study
The Lancet (2019)
Felix Mahfoud, Michael Böhm, Roland Schmieder, Krzysztof Narkiewicz, Sebastian Ewen, Luis Ruilope, Markus Schlaich, Bryan Williams, Martin Fahy and Giuseppe Mancia
Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry.
European Heart Journal (2019)
Lucas Lauder, Sebastian Ewen, Michael Böhm, Bruno Scheller, Felix Mahfoud
Secondary rise in blood pressure and leg swelling after central arteriovenous anastomosis
Clinical Research in Cardiology (2019)
Michael Böhm, Helmut Schumacher, Koon K. Teo, Eva M. Lonn, Felix Mahfoud, Johannes F.E. Mann, Giuseppe Mancia, Josep Redon, Roland E. Schmieder, Nikolaus Marx, Karen Sliwa, Michael A. Weber, Bryan Williams and Salim Yusuf
Cardiovascular outcomes and achieved blood pressure in patients with and without diabetes at high cardiovascular risk.
European Journal of Heart Failure (2019)
Michael Böhm, Felix Mahfoud, Raymond R. Townsend, David E. Kandzari, Stuart Pocock, Christian Ukena, Michael A. Weber, Satoshi Hoshide, Manesh Patel, Crystal C. Tyson, Joachim Weil, Tolga Agdirlioglu, Martin Fahy and Kazuomo Kario
Ambulatory heart rate reduction after catheter-based renal denervation in hypertensive patients not receiving anti-hypertensive medications: data from SPYRAL HTN-OFF MED, a randomized, sham-controlled, proof-of-concept trial.
European Journal of Heart Failure (2019)
Mathias Hohl, PHD, Katharina Erb, Lisa Lang, Sven Ruf, PHD, Thomas Hübschle, PHD, Stefan Dhein, MD, Wolfgang Linz, PHD, Adrian D. Elliott, PHD, Prashanthan Sanders, MBBS, PHD, Olesja Zamyatkin, Michael Böhm, MD, Ulrich Schotten, MD, PHD, Thorsten Sadowski, PHD, Dominik Linz, MD, PHD
Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion
JACC: Basic to Translation Science (2019)
McGuire DK, Alexander JH, Johansen OE, Perkovic V, Rosenstock J, Cooper ME, Wanner C, Kahn SE, Toto RD, Zinman B, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George JT, von Eynatten M, Marx N
Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA.
Circulation (2019)
2018
Moellmann J, Klinkhammer BM, Onstein J, Stöhr R, Jankowski V, Jankowski J, Lebherz C, Tacke F, Marx N, Boor P, Boor P, Lehrke M
Glucagon-Like Peptide 1 and Its Cleavage Products Are Renoprotective in Murine Diabetic Nephropathy.
Diabetes (2018)
Diebold S, Moellmann J, Kahles F, Haj-Yehia E, Liehn EA, Nickel A, Lebherz C, Maack C, Marx N, Lehrke M
Myocardial infarction is sufficient to increase GLP-1 secretion, leading to improved left ventricular contractility and mitochondrial respiratory capacity
Diabetes, Obesity and Metabolism (2018)
Michael Böhm, Helmut Schumacher, Koon K. Teo, Eva M. Lonn, Felix Mahfoud, Christian Ukena, Johannes F.E. Mann, Giuseppe Mancia, Josep Redon, Roland E. Schmieder, Karen Sliwa, Nikolaus Marx, Michael A. Weber, Bryan Williams and Salim Yusuf
Resting heart rate and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk analysis from the ONTARGET/TRANSCEND trials.
European Journal of Heart Failure (2018)
Stephen Zewinger, Thomas Rauen, Michael Rudnicki, Giuseppina Federico, Martina Wagner, Sarah Triem, Stefan J Schunk, Ioannis Petrakis, David Schmit, Stefan Wagenpfeil, Gunnar H Heine, Gert Mayer, Jurgen Floege, Danilo Fliser, Hermann-Josef Grone, Thimoteus Speer
Dickkopf-3 (DKK3) in Urine Identifies Patients with Short-Term Risk of eGFR Loss
Journal of the American Society of Nephrology (2018)
Rosenstock J, Perkovic V, Johansen OE, Cooper ME, Kahn SE, Marx N, Alexander JH, Pencina M, Toto RD, Wanner C, Zinman B, Woerle HJ, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George JT, von Eynatten M, McGuire DK; CARMELINA Investigators.
Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial.
JAMA (2018)
European Heart Journal (2018)
Michael Böhm, Helmut Schumacher, Koon K. Teo, Eva Lonn, Felix Mahfoud, Johannes F.E. Mann, Giuseppe Mancia, Josep Redon, Roland Schmieder, Michael Weber, Karen Sliwa, Bryan Williams, Salim Yusuf.
Achieved diastolic blood pressure and pulse pressure at target systolic blood pressure (120–140mmHg) and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials.
European Heart Journal 2018
Marx N, Noels H, Jankowski J, Floege J, Fliser D, Böhm M.
Mechanisms of cardiovascular complications in chronic kidney disease: research focus of the Transregional Research Consortium SFB TRR219 of the University Hospital Aachen (RWTH) and the Saarland University. Clin Res Cardiol. 2018 May 4.
Clinical Research in Cardiology (2018)
Selejan SR, Linz D, Tatu AM, Hohl M, Speer T, Ewen S, Mahfoud F, Kindermann I, Zamyatkin O, Kazakov A, Laufs U, Böhm M.
Journal of Molecular and Cellular Cardiology (2018)
Noels H, Theelen W, Sternkopf M, Jankowski V, Moellmann J, Kraemer S, Lehrke M, Marx N, Martin L, Marx G, Jankowski J, Goetzenich A, Stoppe C.
Reduced post-operative DPP4 activity associated with worse patient outcome after cardiac surgery.
Scientific Reports (2018)
Christoph Maack, Michael Lehrke, Johannes Backs, Frank R Heinzel, Jean-Sebastien Hulot, Nikolaus Marx, Walter J Paulus, Patrick Rossignol, Heinrich Taegtmeyer, Johann Bauersachs, Antoni Bayes-Genis, Dirk Brutsaert, Heiko Bugger, Kieran Clarke, Francesco Cosentino, Gilles De Keulenaer, Alessandra Dei Cas, Arantxa Gonzalez, Martin Huelsmann, Guido Iaccarino, Ida Gjervold Lunde, Alexander R Lyon, Piero Pollesello, Graham Rena, Niels P Riksen, Giuseppe Rosano, Bart Staels, Linda W Van Laake, Christoph Wanner, Dimitrios Farmakis, Gerasimos Filippatos, Frank Ruschitzka, Petar Seferovic, Rudolf A De Boer, Stephane Heymans
Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology
European Heart Journal (2018)
Andrey Kazakov, Rabea A. Hall, Christian Werner, Timo Meier, André Trouvain, Svetlana Rodionycheva, Alexander Nickel, Frank Lammert, Christoph Maack, Michael Böhm, Ulrich Laufs
Fibrosis is a hallmark of maladaptive cardiac remodelling. Here we report that genome-wide quantitative trait locus (QTL) analyses
in recombinant inbred mouse lines of C57BL/6 J and DBA2/J strains identified Raf Kinase Inhibitor Protein (RKIP) as genetic
marker of fibrosis progression.
Basic Research in Cardiology (2018)
Simina-Ramona Selejana, Dominik Linz, Anna-Maria Tatu, Mathias Hohl, Thimoteus Speer, Sebastian Ewen, Felix Mahfoud, Ingrid Kindermann, Olesja Zamyatkin,
Andrey Kazakov, Ulrich Laufs, Michael Böhm
Receptors-for-Advanced-Glycation-End-products (RAGE) activate pro-inflammatory programs mediated by carboxymethyllysine (CML) and high-mobility-group-box1 protein (HMGB1). The soluble isoform sRAGE neutralizes RAGE-ligands preventing cardiovascular complications in conditions associated with increased sympathetic activation like hypertension and diabetes..
Journal of Molecular and Cellular Cardiology (2018)