Publications

2021
 

Stefan J. Schunk, Jürgen Floege, Danilo Fliser, Thimoteus Speer

WNT–β-catenin signalling — a versatile player in kidney injury and repair

Nature Reviews Nephrology (2020)

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Josefin Soppert, Michael Lehrke, Nikolaus Marx, Joachim Jankowski, Heidi Noels

Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting

Advanced Drug Delivery Reviews (2020)

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Marina A. Heuschkel, Nikolaos T. Skenteris, Joshua D. Hutcheson, Dewy D. van der Valk, Juliane Bremer, Philip Goody, Jesper Hjortnaes, Felix Jansen, Carlijn V.C. Bouten, Antoon van den Bogaerdt, Ljubica Matic, Nikolaus Marx and Claudia Goettsch

Integrative Multi-Omics Analysis in Calcific Aortic Valve Disease Reveals a Link to the Formation of Amyloid-Like Deposits

Cells (2020)

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Stefan J Schunk, Thimoteus Speer, Ioannis Petrakis, Danilo Fliser

Dickkopf 3-a novel biomarker of the 'kidney injury continuum'

Nephrology Dialysis Transplantation (2020)

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Turgay Saritas, Jurgen Floege

Cardiovascular disease in patients with chronic kidney disease

Herz (2020)

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Stephen Zewinger, Jochen Reiser, Vera Jankowski, Dalia Alansary, Eunsil Hahm, Sarah Triem, Mira Klug, Stefan J Schunk, David Schmit, Rafael Kramann, Christina Korbel, Emmanuel Ampofo, Matthias W Laschke, Simina-Ramona Selejan, Anna Paschen, Tobias Herter, Susanne Schuster, Gunther Silbernagel, Martina Sester, Urban Sester, Gunter Assmann, Robert Bals, Gerhard Kostner, Willi Jahnen-Dechent, Michael D Menger, Lucia Rohrer, Winfried Marz, Michael Bohm, Joachim Jankowski, Manfred Kopf, Eicke Latz, Barbara A Niemeyer, Danilo Fliser, Ulrich Laufs, Thimoteus Speer

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

Nature Immunology (2020)

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Marieke Sternkopf, Magdolna Nagy, Constance C F M J Baaten, Marijke J E Kuijpers, Bibian M E Tullemans, Julia Wirth, Wendy Theelen, Tom G Mastenbroek, Michael Lehrke, Benjamin Winnerling, Lesley Baerts, Nikolaus Marx, Ingrid De Meester, Yvonne Doring, Judith M E M Cosemans, Andreas Daiber, Sebastian Steven, Joachim Jankowski, Johan W M Heemskerk, Heidi Noels

Native, Intact Glucagon-Like Peptide 1 Is a Natural Suppressor of Thrombus Growth Under Physiological Flow Conditions

Arteriosclerosis, Thrombosis, and Vascular Biology (2020)

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Albert J. Omlor, Franziska C. Trudzinski,  Mohamad Alqudrah, Frederik Seiler, Frank Biertz,  Claus F. Vogelmeier, Tobias Welte, Henrik Watz, Benjamin Waschki, Titus J. Brinker, Stefan Andreas, Sebastian Fähndrich, Peter Alter, Rudolf A. Jörres, Michael Böhm, Robert Bals on behalf of German COSYCONET Cohort

Time‑updated resting heart rate predicts mortality in patients with COPD.

Clinical Research in Cardiology  (2019)

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Heidi Noels, Joachim Jankowski

Editorial on the Special Issue "Comorbidities in Chronic Kidney Disease"

Toxins (2020)

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Julia Moellmann, Barbara M Klinkhammer, Patrick Droste, Ben Kappel, Elias Haj-Yehia, Sebastian Maxeiner, Anna Artati, Jerzy Adamski, Peter Boor, Katharina Schutt, Gary D Lopaschuk, Subodh Verma, Nikolaus Marx, Michael Lehrke

Empagliflozin improves left ventricular diastolic function of db/db mice

Biochimica et Biophysica Acta - Molecular Basis of Disease (2020)

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Bilal Mir, Claudia Goettsch

Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo

 

Cells (2020)

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Benedikt Linz, Mathias Hohl, Ricardo Mishima, Arnela Saljic, Dennis H. Lau,
Thomas Jespersen, Ulrich Schotten, Prashanthan Sanders, Dominik Linz

Pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut reduces atrial fibrillation susceptibility in obese spontaneously hypertensive rats

 

IJC Heart & Vasculature (2020)

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Florian Kahles, Marcia V Ruckbeil, Robert W Mertens, Ann C Foldenauer, Maria C Arrivas, Julia Moellmann, Corinna Lebherz, Moritz Biener, Evangelos Giannitsis, Hugo A Katus, Nikolaus Marx, Michael Lehrke

Glucagon-like peptide 1 levels predict cardiovascular risk in patients with acute myocardial infarction

European Heart Journal (2020)

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Nadine Kaesler, Claudia Goettsch, Daniel Weis, Leon Schurgers, Burkhard Hellmann, Jurgen Floege, Rafael Kramann

 

Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia

 

Nephrology Dialysis Transplantation (2019)

 

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Nadine Kaesler, Anne Babler, Jurgen Floege, Rafael Kramann

 

Cardiac Remodeling in Chronic Kidney Disease

 

Toxins (2020)

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Jana Holmar, Heidi Noels, Michael Bohm, Shruti Bhargava, Joachim Jankowski, Setareh Orth-Alampour

 

Development, establishment and validation of in vitro and ex vivo assays of vascular calcification

 

Biochemical and Biophysical Research Communications (2020)

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Jana Holmar, Sofia de la Puente-Secades, Jürgen Floege, Heidi Noels, Joachim Jankowski and Setareh Orth-Alampour

Uremic Toxins Affecting Cardiovascular Calcification: A Systematic Review

 

Cells (2020)

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Mathias Hohl, Manuel Mayr, Lisa Lang, Alexander G. Nickel , Javier Barallobre-Barreiro, Xiaoke Yin ,Thimoteus Speer, Simina-Ramona Selejan, Claudia Goettsch, Katharina Erb, Claudia Fecher-Trost, Jan-Christian Reil, Benedikt Linz, Sven Ruf, Thomas Hübschle, Christoph Maack, Michael Böhm, Thorsten Sadowski, Dominik Linz 

Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice

 

JBC Journal (2020)

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Anika Himmelsbach, Carina Ciliox, Claudia Goettsch

Cardiovascular Calcification in Chronic Kidney Disease-Therapeutic Opportunities

Toxins (2020)

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Marietta Herrmann, Anne Babler, Irina Moshkova, Felix Gremse, Fabian Kiessling, Ulrike Kusebauch, Valentin Nelea, Rafael Kramann, Robert L Moritz, Marc D Mckee, Willi Jahnen-Dechent

 

Lumenal calcification and microvasculopathy in fetuin-A-deficient mice lead to multiple organ morbidity

 

PLoS One

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Juliane Hermann, Heidi Noels, Wendy Theelen, Michaela Lellig, Setareh Orth-Alampour, Peter Boor, Vera Jankowski, Joachim Jankowski

 

Sample preparation of formalin-fixed paraffin-embedded tissue sections for MALDI-mass spectrometry imaging

 

Analytical and Bioanalytical Chemistry (2020)

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Francesco Giorgino, Irene Caruso, Julia Moellmann, Michael Lehrke

Differential indication for SGLT-2 inhibitors versus GLP-1 receptor agonists in patients with established atherosclerotic heart disease or at risk for congestive heart failure

 

Metabolism (2020)

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Michael Böhm, Jonathan Slawik, Martina Brueckmann, Michaela Mattheus, Jyothis T. George, Anne Pernille Ofstad, Silvio E. Inzucchi, David Fitchett, Stefan D. Anker, Nikolaus Marx, Christoph Wanner, Bernard Zinman and Subodh Verma

Efficacy of empagliflozin on heart failure and renal outcomes in patients with atrial fibrillation: data from the EMPA-REG OUTCOME trial.

European Journal of Heart Failure (2019)

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Michael Böhm, Helmut Schumacher, Koon K. Teo, Eva M. Lonn, Felix Mahfoud, Christian Ukena, Johannes F.E. Mann, Giuseppe Mancia, Josep Redon, Roland E. Schmieder, Karen Sliwa, Nikolaus Marx, Michael A. Weber, Bryan Williams and Salim Yusuf

Resting heart rate and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk analysis from the ONTARGET/TRANSCEND trials.

European Journal of Heart Failure (2018)

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Michael Böhm, Kazuomi Kario, David E Kandzari, Felix Mahfoud, Michael A Weber, Roland E Schmieder, Konstantinos Tsioufis, Stuart Pocock, Dimitris Konstantinidis, James W Choi, Cara East, David P Lee, Adrian Ma, Sebastian Ewen, Debbie L Cohen, Robert Wilensky, Chandan M Devireddy, Janice Lea, Axel Schmid, Joachim Weil, Tolga Agdirlioglu, Denise Reedus, Brian K Jefferson, David Reyes, Richard D’Souza, Andrew S P Sharp, Faisal Sharif, Martin Fahy, Vanessa DeBruin, Sidney A Cohen, Sandeep Brar, Raymond R Townsend, on behalf of the SPYRAL HTN-OFF MED Pivotal Investigators

Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial

The Lancet (2020)

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Martin Berger, Marcus E Kleber, Graciela E Delgado, Winfred Marz, Meinitzer Andreas, Peter Hellstern, Nikolaus Marx, Katharina A Schuett

 

Trimethylamine N-Oxide and Adenosine Diphosphate-Induced Platelet Reactivity Are Independent Risk Factors for Cardiovascular and All-Cause Mortality

 

Circulation Research (2020)

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Anne Babler, Carlo Schmitz, Andrea Buescher, Marietta Herrmann, Felix Gremse, Theo Gorgels, Juergen Floege, Willi Jahnen-Dechent

 

Microvasculopathy and soft tissue calcification in mice are governed by fetuin-A, magnesium and pyrophosphate

 

PLoS One (2020)

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Sean S. Scholz, Markus Dillmann, Alexander Flohr, Christina Backes, Tobias Fehlmann, Dominic Millenaar, Christian Ukena, Michael Böhm, Andreas Keller, Felix Mahfoud

Contemporary scientometric analyses using a novel web application: the science performance evaluation (SciPE) approach.

Clinical Research in Cardiology  (2019)

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Sean S. Scholz, Lucas Lauder, Sebastian Ewen, Kulenthiran Saarraaken, Nikolaus Marx, Orazbek Sakhov, Floris Kauer, Adam Witkowski, Marco Vaglimigli, William Wijns, Bruno Scheller, Michael Böhm, Felix Mahfoud

One‑year clinical outcomes in patients with renal insufficiency after contemporary PCI: data from a multicenter registry.

Clinical Research in Cardiology  (2019)

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Sean S. Scholz, MD; Davor Vukadinović, MD; Lucas Lauder, MD; Sebastian Ewen, MD; Christian Ukena, MD; Raymond R. Townsend, MD; Stefan Wagenpfeil, PhD; Michael B€ohm, MD; Felix Mahfoud, MD

Effects of Arteriovenous Fistula on Blood Pressure in Patients With End-Stage Renal Disease:

A Systematic Meta-Analysis.

Journal of the American Heart Association (2019)

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Jonathan Slawik, Lucas Adrian, Mathias Hohl, Sarah Lothschütz, Ulrich Laufs and Michael Böhm

Irregular pacing of ventricular cardiomyocytes induces pro-fibrotic signalling involving paracrine effects of transforming growth factor beta and connective tissue growth factor.

European Journal of Heart Failure (2019)

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Christian Ukena, Tobias Seidel, Konstantinos Rizas, Davide Scarsi, Dominic Millenaar, Sebastian Ewen, Axel Bauer, Felix Mahfoud, Michael Böhm

Effects of renal denervation on 24‑h heart rate and heart rate variability in resistant hypertension.

Clinical Research in Cardiology (2019)

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Davor Vukadinović, Sean S. Scholz, Franz H. Messerli, Michael A. Weber, Bryan Williams, Michael Böhm and Felix Mahfoud

Peripheral edema and headache associated with amlodipine treatment: a meta-analysis of randomized, placebo-controlled trials.

JournalofHypertension (2019)

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Christian M. Werner, Anne Hecksteden, Arne Morsch, Joachim Zundler, Melissa Wegmann, Jurgen Kratzsch, Joachim Thiery, Mathias Hohl, Jörg Thomas Bittenbring, Frank Neumann, Michael Böhm, Tim Meyer and Ulrich Laufs

Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study.

European Heart Journal (2019)

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Qinxue Sun, Maike Baues, Barbara M Klinkhammer, Josef Ehling, Sonja Djudjaj, Natascha I Drude, Christoph Daniel, Kerstin Amann, Rafael Kramann, Hyojin Kim, Julio Saez-Rodriguez, Ralf Weiskirchen, David C Onthank, Rene M Botnar, Fabian Kiessling, Jurgen Floege, Twan Lammers, Peter Boor

Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis

Science Translational Medicine (2019)

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Marieke Sternkopf, Sven Thoroe-Boveleth, Tobias Beck, Kirsten Oleschko, Ansgar Erlenkotter, Ulrich Tschulena, Sonja Steppan, Thimoteus Speer, Claudia Goettsch, Vera Jankowski, Joachim Jankowski, Heidi Noels, Eutox European Uremic Toxin Work Group

A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients

Toxins (2019)

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Stefan J Schunk, Alexander Zarbock, Melanie Meersch, Mira Kullmar, John A Kellum, David Schmit, Martina Wagner, Sarah Triem, Stefan Wagenpfeil, Hermann-Josef Grone, Hans-Joachim Schafers, Danilo Fliser, Thimoteus Speer, Stephen Zewinger

Association between urinary dickkopf-3, acute kidney injury, and subsequent loss of kidney function in patients undergoing cardiac surgery: an observational cohort study

The Lancet (2019)

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David Schmit, Danilo Fliser, Thimoteus Speer

 

Proprotein convertase subtilisin/kexin type 9 in kidney disease

Nephrology Dialysis Transplantation (2019)

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Julio Saez-Rodriguez, Markus M Rinschen, Jurgen Floege, Rafael Kramann

Big science and big data in nephrology

Kidney International (2019)

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Heidi Noels, Christian Weber, Rory R Koenen

Chemokines as Therapeutic Targets in Cardiovascular Disease

Arteriosclerosis, Thrombosis, and Vascular Biology (2019)

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Felix Mahfoud, Michael Böhm, Roland Schmieder, Krzysztof Narkiewicz, Sebastian Ewen, Luis Ruilope, Markus Schlaich, Bryan Williams, Martin Fahy and Giuseppe Mancia

Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry.

European Heart Journal (2019)

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Lucas Lauder, Sebastian Ewen,  Michael Böhm,  Bruno Scheller,  Felix Mahfoud

Secondary rise in blood pressure and leg swelling after central arteriovenous anastomosis

Clinical Research in Cardiology (2019)

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Laura Jahn, Rafael Kramann, Nikolaus Marx, Jürgen Floege, Michael Becker, Georg Schlieper

Speckle Tracking Echocardiography and All-Cause and Cardiovascular Mortality Risk in Chronic Kidney Disease Patients

Kidney and Blood Pressure Research (2019)

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Michael Böhm, Helmut Schumacher, Koon K. Teo, Eva M. Lonn, Felix Mahfoud, Johannes F.E. Mann, Giuseppe Mancia, Josep Redon, Roland E. Schmieder, Nikolaus Marx, Karen Sliwa, Michael A. Weber, Bryan Williams and Salim Yusuf

Cardiovascular outcomes and achieved blood pressure in patients with and without diabetes at high cardiovascular risk.

European Journal of Heart Failure (2019)

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Michael Böhm, Felix Mahfoud, Raymond R. Townsend, David E. Kandzari, Stuart Pocock, Christian Ukena, Michael A. Weber, Satoshi Hoshide, Manesh Patel, Crystal C. Tyson, Joachim Weil, Tolga Agdirlioglu, Martin Fahy and Kazuomo Kario

Ambulatory heart rate reduction after catheter-based renal denervation in hypertensive patients not receiving anti-hypertensive medications: data from SPYRAL HTN-OFF MED, a randomized, sham-controlled, proof-of-concept trial.

European Journal of Heart Failure (2019)

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Mathias Hohl, PHD, Katharina Erb, Lisa Lang, Sven Ruf, PHD, Thomas Hübschle, PHD, Stefan Dhein, MD, Wolfgang Linz, PHD, Adrian D. Elliott, PHD, Prashanthan Sanders, MBBS, PHD, Olesja Zamyatkin, Michael Böhm, MD, Ulrich Schotten, MD, PHD, Thorsten Sadowski, PHD, Dominik Linz, MD, PHD

Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion

JACC: Basic to Translation Science (2019)

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McGuire DK, Alexander JH, Johansen OE, Perkovic V, Rosenstock J, Cooper ME, Wanner C, Kahn SE, Toto RD, Zinman B, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George JT, von Eynatten M, Marx N

Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA.

Circulation (2019)

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Stephen Zewinger, Thomas Rauen, Michael Rudnicki, Giuseppina Federico, Martina Wagner, Sarah Triem, Stefan J Schunk, Ioannis Petrakis, David Schmit, Stefan Wagenpfeil, Gunnar H Heine, Gert Mayer, Jurgen Floege, Danilo Fliser, Hermann-Josef Grone, Thimoteus Speer

Dickkopf-3 (DKK3) in Urine Identifies Patients with Short-Term Risk of eGFR Loss

Journal of the American Society of Nephrolog (2018)

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Rosenstock J, Perkovic V, Johansen OE, Cooper ME, Kahn SE, Marx N, Alexander JH, Pencina M, Toto RD, Wanner C, Zinman B, Woerle HJ, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George JT, von Eynatten M, McGuire DK; CARMELINA Investigators.

Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial. 

JAMA (2018)

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Jonathan Slawik, Lucas Adrian, Mathias Hohl, Sarah Lothschütz, Ulrich Laufs and Michael Böhm

Irregular pacing of ventricular cardiomyocytes induces pro-fibrotic signalling involving paracrine effects of transforming growth factor beta and connective tissue growth factor.

European Journal of Heart Failure

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Christian M Werner, Anne Hecksteden, Arne Morsch, Joachim Zundler, Melissa Wegmann, Jürgen Kratzsch, Joachim Thiery, Mathias Hohl, Jörg Thomas Bittenbring, Frank Neumann, Michael Böhm, Tim Meyer, Ulrich Laufs.

Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study European Heart Journal 2018.

Press release by the European Society for Cardiology   -->

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Michael Böhm, Helmut Schumacher, Koon K. Teo, Eva Lonn, Felix Mahfoud, Johannes F.E. Mann, Giuseppe Mancia, Josep Redon, Roland Schmieder, Michael Weber, Karen Sliwa, Bryan Williams, Salim Yusuf.

Achieved diastolic blood pressure and pulse pressure at target systolic blood pressure (120–140mmHg) and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials.

European Heart Journal 2018

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Marx N, Noels H, Jankowski J, Floege J, Fliser D, Böhm M.

Mechanisms of cardiovascular complications in chronic kidney disease: research focus of the Transregional Research Consortium SFB TRR219 of the University Hospital Aachen (RWTH) and the Saarland University. Clin Res Cardiol. 2018 May 4.

Springer Link

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Selejan SR, Linz D, Tatu AM, Hohl M, Speer T, Ewen S, Mahfoud F, Kindermann I, Zamyatkin O, Kazakov A, Laufs U, Böhm M.

Sympathoadrenergic suppression improves heart function by upregulating the ratio of sRAGE/RAGE in hypertension with metabolic syndrome.

J Mol Cell Cardiol. 2018;122:34-46.

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Noels H, Theelen W, Sternkopf M, Jankowski V, Moellmann J, Kraemer S, Lehrke M, Marx N, Martin L, Marx G, Jankowski J, Goetzenich A, Stoppe C.

Reduced post-operative DPP4 activity associated with worse patient outcome after cardiac surgery.

Sci Rep. 2018;8:11820

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Christoph Maack, Michael Lehrke, Johannes Backs, Frank R Heinzel, Jean-Sebastien Hulot, Nikolaus Marx, Walter J Paulus, Patrick Rossignol, Heinrich Taegtmeyer, Johann Bauersachs, Antoni Bayes-Genis, Dirk Brutsaert, Heiko Bugger, Kieran Clarke, Francesco Cosentino, Gilles De Keulenaer, Alessandra Dei Cas, Arantxa Gonzalez, Martin Huelsmann, Guido Iaccarino, Ida Gjervold Lunde, Alexander R Lyon, Piero Pollesello, Graham Rena, Niels P Riksen, Giuseppe Rosano, Bart Staels, Linda W Van Laake, Christoph Wanner, Dimitrios Farmakis, Gerasimos Filippatos, Frank Ruschitzka, Petar Seferovic, Rudolf A De Boer, Stephane Heymans

Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology

European Heart Journal

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Andrey Kazakov, Rabea A. Hall, Christian Werner, Timo Meier, André Trouvain, Svetlana Rodionycheva, Alexander Nickel, Frank Lammert, Christoph Maack, Michael Böhm, Ulrich Laufs​​

Raf kinase inhibitor protein mediates myocardial fibrosis under conditions of enhanced myocardial oxidative stress

 

Fibrosis is a hallmark of maladaptive cardiac remodelling. Here we report that genome-wide quantitative trait locus (QTL) analyses
in recombinant inbred mouse lines of C57BL/6 J and DBA2/J strains identified Raf Kinase Inhibitor Protein (RKIP) as genetic
marker of fibrosis progression.

 

European Heart Journal 2018.

 

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Simina-Ramona Selejana, Dominik Linz, Anna-Maria Tatu, Mathias Hohl, Thimoteus Speer, Sebastian Ewen, Felix Mahfoud, Ingrid Kindermann, Olesja Zamyatkin,

Andrey Kazakov, Ulrich Laufs, Michael Böhm

Sympathoadrenergic suppression improves heart function by upregulating the ratio of sRAGE/RAGE in hypertension with metabolic syndrome

 

Receptors-for-Advanced-Glycation-End-products (RAGE) activate pro-inflammatory programs mediated by carboxymethyllysine (CML) and high-mobility-group-box1 protein (HMGB1). The soluble isoform sRAGE neutralizes RAGE-ligands preventing cardiovascular complications in conditions associated with increased sympathetic activation like hypertension and diabetes..

 

Journal of Molecular and Cellular Cardiology

 

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