PhD MD TRR219-associated students
Robert Werner Mertens
University Hospital RWTH Aachen
Department of Internal Medicine
Project: The role of incretin hormone GLP-2 in septic cardiomyopathy
PI: Michael Lehrke
GLP-2 is an incretin hormone secreted from intestinal L-cells without direct insulinotropic effects that is able to improve nutrient absorption and decrease permeability in the gut and has recently been shown to be upregulated in patients with colitis. However, its role in acute inflammatory settings is still unknown.
The aim of our project is to investigate the effect of GLP-2 in sepsis and septic cardiomyopathy in a murine sepsis model.