Shruti Bhargava

PhD student – Marie Curie ITN INCTRICARE

University Hospital RWTH Aachen

Institute for Molecular

Cardiovascular Research

Project: Characterization of the recently identified “Calcification blocking factor” (CBF) and isolation of unknown mediators inhibiting calcification processes.

PI: Joachim Jankowski

This project has the following objectives:

- To identify the active site of CBF

- Development of a peptide mimic for therapeutic application of CBF

-Study the impact of this peptide in the context of isolated systolic hypertension

- Screen chromatographic fractions from Adrenal glands and plasma to identify the unknown Mediators involved in the calcification process