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Mathias Hohl, PHD, Katharina Erb, Lisa Lang, Sven Ruf, PHD, Thomas Hübschle, PHD, Stefan Dhein, MD, Wolfgang Linz, PHD, Adrian D. Elliott, PHD, Prashanthan Sanders, MBBS, PHD, Olesja Zamyatkin, Michael Böhm, MD, Ulrich Schotten, MD, PHD, Thorsten Sadowski, PHD, Dominik Linz, MD, PHD

Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion


JUNE 2019:332 – 4 4

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McGuire DK, Alexander JH, Johansen OE, Perkovic V, Rosenstock J, Cooper ME, Wanner C, Kahn SE, Toto RD, Zinman B, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George JT, von Eynatten M, Marx N

Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA.

Circulation. 2019 Jan 15;139(3):351-361;

Rosenstock J, Perkovic V, Johansen OE, Cooper ME, Kahn SE, Marx N, Alexander JH, Pencina M, Toto RD, Wanner C, Zinman B, Woerle HJ, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George JT, von Eynatten M, McGuire DK; CARMELINA Investigators.

Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial. 

JAMA. 2018 Nov 9. doi: 10.1001/jama.2018.18269

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Jonathan Slawik, Lucas Adrian, Mathias Hohl, Sarah Lothschütz, Ulrich Laufs and Michael Böhm

Irregular pacing of ventricular cardiomyocytes induces pro-fibrotic signalling involving paracrine effects of transforming growth factor beta and connective tissue growth factor.

European Journal of Heart Failure

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Christian M Werner, Anne Hecksteden, Arne Morsch, Joachim Zundler, Melissa Wegmann, Jürgen Kratzsch, Joachim Thiery, Mathias Hohl, Jörg Thomas Bittenbring, Frank Neumann, Michael Böhm, Tim Meyer, Ulrich Laufs.

Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study European Heart Journal 2018.

Press release by the European Society for Cardiology   -->

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Michael Böhm, Helmut Schumacher, Koon K. Teo, Eva Lonn, Felix Mahfoud, Johannes F.E. Mann, Giuseppe Mancia, Josep Redon, Roland Schmieder, Michael Weber, Karen Sliwa, Bryan Williams, Salim Yusuf.

Achieved diastolic blood pressure and pulse pressure at target systolic blood pressure (120–140mmHg) and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials.

European Heart Journal 2018.

Marx N, Noels H, Jankowski J, Floege J, Fliser D, Böhm M.

Mechanisms of cardiovascular complications in chronic kidney disease: research focus of the Transregional Research Consortium SFB TRR219 of the University Hospital Aachen (RWTH) and the Saarland University. Clin Res Cardiol. 2018 May 4.

Selejan SR, Linz D, Tatu AM, Hohl M, Speer T, Ewen S, Mahfoud F, Kindermann I, Zamyatkin O, Kazakov A, Laufs U, Böhm M.

Sympathoadrenergic suppression improves heart function by upregulating the ratio of sRAGE/RAGE in hypertension with metabolic syndrome.

J Mol Cell Cardiol. 2018;122:34-46.

Noels H, Theelen W, Sternkopf M, Jankowski V, Moellmann J, Kraemer S, Lehrke M, Marx N, Martin L, Marx G, Jankowski J, Goetzenich A, Stoppe C.

Reduced post-operative DPP4 activity associated with worse patient outcome after cardiac surgery.

Sci Rep. 2018;8:11820


Andrey Kazakov, Rabea A. Hall, Christian Werner, Timo Meier, André Trouvain, Svetlana Rodionycheva, Alexander Nickel, Frank Lammert, Christoph Maack, Michael Böhm, Ulrich Laufs​​

Raf kinase inhibitor protein mediates myocardial fibrosis under conditions of enhanced myocardial oxidative stress


Fibrosis is a hallmark of maladaptive cardiac remodelling. Here we report that genome-wide quantitative trait locus (QTL) analyses
in recombinant inbred mouse lines of C57BL/6 J and DBA2/J strains identified Raf Kinase Inhibitor Protein (RKIP) as genetic
marker of fibrosis progression.


European Heart Journal 2018.


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Simina-Ramona Selejana, Dominik Linz, Anna-Maria Tatu, Mathias Hohl, Thimoteus Speer, Sebastian Ewen, Felix Mahfoud, Ingrid Kindermann, Olesja Zamyatkin,

Andrey Kazakov, Ulrich Laufs, Michael Böhm

Sympathoadrenergic suppression improves heart function by upregulating the ratio of sRAGE/RAGE in hypertension with metabolic syndrome


Receptors-for-Advanced-Glycation-End-products (RAGE) activate pro-inflammatory programs mediated by carboxymethyllysine (CML) and high-mobility-group-box1 protein (HMGB1). The soluble isoform sRAGE neutralizes RAGE-ligands preventing cardiovascular complications in conditions associated with increased sympathetic activation like hypertension and diabetes..


Journal of Molecular and Cellular Cardiology


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