IRTG Journal Club

2021


21.01.2021
Linsey Peters
Finney et al. (2017)
„EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis.“
Circulation. 2017 Aug 8;136(6):566-582. doi: 10.1161/CIRCULATIONAHA.116.026644. Epub 2017 May 9.

28.01.2021
Maren Gesper
Li et al. (2018)
„Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis.“
Lab Invest. 2019 Mar;99(3):346-357. doi: 10.1038/s41374-018-0091-y. Epub 2018 Aug 1.

18.02.2021
Maria Chiara Arrivas
Frodermann et al. (2019)
„Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells.“
Nat Med. 2019 Nov;25(11):1761-1771. doi: 10.1038/s41591-019-0633-x. Epub 2019 Nov 7.

25.02.2021
Sophie Kathrin Schiestel
Li et al. (2017)
„Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.“
Cell Metab. 2017 Oct 3;26(4):672-685.e4. doi: 10.1016/j.cmet.2017.08.019. Epub 2017 Sep 14.

04.03.2021
Marina Augusto Heuschkel
Allapanet et al. (2020)
„Warfarin Accelerates Medial Arterial Calcification in Humans.”
Arterioscler Thromb Vasc Biol. 2020 May;40(5):1413-1419. doi: 10.1161/ATVBAHA.119.313879. Epub 2020 Feb 13.

11.03.2021
Michaela Lellig
Ji et al. (2019)
„Alarmone Ap4A is elevated by aminoglycosideantibiotics and enhances their bactericidal activity.“
Proc Natl Acad Sci USA. 2019 May 7;116(19):9578-9585. doi: 10.1073/pnas.1822026116. Epub 2019 Apr 19.


18.03.2021
Pascal Mann
Wang et al. (2016)
„Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.”
Cell. 2016 Sep 8;166(6):1512-1525.e12. doi: 10.1016/j.cell.2016.07.026.

24.03.2021
Rogier Veltrop
Ikeda et al. (2020)
„Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium.“
J Am Coll Cardiol. 2021 Mar 2;77(8):1073-1088. doi: 10.1016/j.jacc.2020.12.060.

Zuppinger et al. (2017)
„Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes.”
Eur J Histochem. 2017 Jun 21;61(2):2763. doi: 10.4081/ejh.2017.2763.

08.04.2021
Sai Sahana Sundararaman
Li et al. (2021)
„Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression.“
Ren Fail. 2021 Dec;43(1):465-476. doi: 10.1080/0886022X.2021.1881554.

15.04.2021
Jonas Heyn
Brestoff et al. (2021)
„Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity.“
Cell Metab. 2021 Feb 2;33(2):270-282.e8. doi: 10.1016/j.cmet.2020.11.008. Epub 2020 Dec 4.

22.04.2021
Sebastian Maxeiner
Shi et al. (2021)
„Neutrophils can promote clotting via FXI and impact clot structure via neutrophil extracellular traps in a distinctive manner in vitro.“
Sci Rep. 2021 Jan 18;11(1):1718. doi: 10.1038/s41598-021-81268-7.

29.04.2021
Shruti Bhargava
Cobb et al. (2021)
„Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis of Vascular Smooth Muscle Cells.”
Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1339-1357. doi: 10.1161/ATVBAHA.120.315206. Epub 2020 Dec 24.

06.05.2021
Sofia De la Puente Secades
Martinez-Moreno et al. (2017)
„High phosphate induces a pro-inflammatory response by vascular smooth muscle cells and modulation by vitamin D derivatives.”
Clin Sci (Lond). 2017 Jun 28;131(13):1449-1463. doi: 10.1042/CS20160807. Print 2017 Jul 1.

20.05.2021
Valeria Saar-Kovrov
Furmanik et al. (2020)
„Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification.“
Circ Res. 2020 Sep 11;127(7):911-927. doi: 10.1161/CIRCRESAHA.119.316159. Epub 2020 Jun 22.

17.06.2021
Anika Himmelsbach
Gu et al. (2019)
„Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcification.”
Exp Mol Med. 2019 Jul 10;51(7):1-14. doi: 10.1038/s12276-019-0272-9.

24.06.2021
Andrea Bonnin-Marquez
Baba et al. (2020)
„CXCR4-Binding Positron Emission Tomography Tracers Link Monocyte Recruitment and Endothelial Injury in Murine Atherosclerosis.”
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):822-836. doi: 10.1161/ATVBAHA.120.315053. Epub 2020 Dec 17.

19.08.2021
Christian Hemmers
Chung et al. (2019)
„Mitochondrial damage and activation of the STING pathway leads to renal inflammation and fibrosis.“
Cell Metab. 2019 Oct 1;30(4):784-799.e5. doi: 10.1016/j.cmet.2019.08.003. Epub 2019 Aug 29.

26.08.2021
Constance Baaten
Lin et al. (2021)“
Establishment of a Bernard-Soulier syndrome model in zebrafish.”
Haematologica. 2021 Aug 19.doi: 10.3324/haematol.2021.278893     

 

02.09.2021

Dustin Mikolajetz

Yao et al. (2021)

„Shifting osteogenesis in vascular calcification.”

JCI Insight. 2021 May 24;6(10):e143023. doi: 10.1172/jci.insight.143023.

 

09.09.2021

Federica Cascone

Baldassarre et al. (2021)

“Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications.”

Hepatology. 2021 Mar 12. doi: 10.1002/hep.31798.

 

16.09.2021

Giulia Ilaria Bagarolo

Lemesle et al. (2020)

„Apolipoprotein Proteomic Profiling for the Prediction of Cardiovascular Death in Patients with Heart Failure.“

Proteomics Clin Appl. 2020 Nov;14(6):e2000035. doi: 10.1002/prca.202000035. Epub 2020 Sep 28.

 

23.09.2021

Luis Quintana

Xin et al. (2013)

„Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.“

Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619.

 

30.09.2021

Jane Lauxen

Kim et al. (2017)

“Increased Neutrophil Extracellular Trap Formation in Uremia Is Associated with Chronic Inflammation and Prevalent Coronary Artery Disease.”

J Immunol Res. 2017;2017:8415179. doi: 10.1155/2017/8415179. Epub 2017 Mar 27.

 

07.10.2021

Julia Wirth

O’Sullivan et al. (2019)

“Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease

With Renal Inflammation and Cardiac Dysfunction”

Front Physiol. 2019 Nov 15;10:1365. doi: 10.3389/fphys.2019.01365. eCollection 2019.

 

14.10.2021

Hoda Alibiglou

Petsophonsakul et al. (2021)

"Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular

vesicle release in vascular smooth muscle cells"

Cardiovasc Res. 2021 Jul 17;cvab244. doi: 10.1093/cvr/cvab244. Online ahead of print.

 

21.10.2021

Linsey Peters

Yadati et al. (2021)

“Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammation in NASH Mice.”

Front Immunol. 2021 Jul 16;12:675535. doi: 10.3389/fimmu.2021.675535. eCollection 2021.

 

28.10.2021

Maren Gesper

Shil et al. (2021)

“Artificial Sweeteners Negatively Regulate Pathogenic Characteristics of Two Model Gut Bacteria, E. coli and E. faecalis.”

Int J Mol Sci. 2021 May 15;22(10):5228. doi: 10.3390/ijms22105228.

 

04.11.2021

Marina Augusto Heuschkel

Jaiswal et al. (2017)

“Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.”

N Engl J Med. 2017 Jul 13;377(2):111-121. doi: 10.1056/NEJMoa1701719. Epub 2017 Jun 21.

 

11.11.2021

Maria Chiara Arrivas

Barrett et al. (2021)

“Chronic stress primes innate immune responses in mice and humans.”

Cell Rep. 2021. PMID: 34496250

 

18.11.2021

Maximilian Sausen

He et al. (2019)

“Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.”

Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30.

2020

16.01.2020

Josefin Soppert

Pouwer et al. (2020)

“Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice.”

J Lipid Res. 2020 Mar;61(3):365-375. doi: 10.1194/jlr.RA119000419. Epub 2019 Dec 16.

 

23.01.2020

Pascal Mann

Ho et al. (2019)

“Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.”

Cardiovasc Res. 2019 Sep 1;115(11):1606-1616. doi: 10.1093/cvr/cvz045.

 

30.01.2020

Julia Wirth

Jiang et a. (2019)

“Endothelial cell modulation of cardiomyocyte gene expression.”

Exp Cell Res. 2019 Oct 15;383(2):111565. doi: 10.1016/j.yexcr.2019.111565. Epub 2019 Aug 20.

 

13.02.2020

Kabita Pradhan

Zhao et al. (2018)

“Cardiomyocyte Derived miR-328 Promotes Cardiac Fibrosis by Paracrinely Regulating Adjacent Fibroblasts.”

Cell Physiol Biochem. 2018;46(4):1555-1565. doi: 10.1159/000489201. Epub 2018 Apr 19.

 

27.02.2020

Katja Krüger

Oleinik et al. (2019)

“Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress.”

Sci Adv. 2019 Sep 11;5(9):eaax1978. doi: 10.1126/sciadv.aax1978. eCollection 2019 Sep.

 

05.03.2020

Linsey Peters

Negishi et al. (2008)

“A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.”

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20446-51. doi: 10.1073/pnas.0810372105. Epub 2008 Dec 11

 

07.05.2020

Mareike Staudt

Rosshart et al. (2019)

"Laboratory mice born to wild mice have natural microbiota and model human immune responses.”

Science. 2019 Aug 2;365(6452):eaaw4361. doi: 10.1126/science.aaw4361. Epub 2019 Aug 1.

 

14.05.2020

Marina Augusto Heuschkel

Zhang et al. (2020)

“Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals.”

Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):751-765. doi: 10.1161/ATVBAHA.119.313414. Epub 2020 Jan 16.

 

28.05.2020

Maria Chiara Arrivas

McAlpine et al. (2019)

“Sleep modulates haematopoiesis and protects against atherosclerosis.”

Nature. 2019 Feb;566(7744):383-387. doi: 10.1038/s41586-019-0948-2. Epub 2019 Feb 13.

 

04.06.2020

Maren Gesper

Tang et al. (2019)

“Loss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair.”

Circulation. 2019 Jan 29;139(5):647-659. doi: 10.1161/CIRCULATIONAHA.118.035235.

 

18.06.2020

Pascal Mann

Kim et al. (2020)

“SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease.”

Nat Commun. 2020 May 1;11(1):2127. doi: 10.1038/s41467-020-15983-6.

 

13.08.2020

Sofia de la Puente Secades

De Maré et al. (2019)

„Sclerostin as Regulatory Molecule in Vascular Media Calcification and the Bone–Vascular Axis.“

Toxins (Basel). 2019 Jul 21;11(7):428. doi: 10.3390/toxins11070428.

 

20.08.2020

Sebastian Maxeiner

Wilbs et al. (2020)

„Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs.“

Nat Commun. 2020 Aug 4;11(1):3890. doi: 10.1038/s41467-020-17648-w.

 

27.08.2020

Shruti Bhargava

Lino et al. (2018)

„Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1

via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis.“

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1878-1889. doi: 10.1161/ATVBAHA.118.311238.

 

03.09.2020

Sai Sahana Sundararaman

Li et al. (2020)

„A novel function of calcium sensing receptor in chronic hypoxia- induced pulmonary venous smooth muscle cells proliferation.“

Hypertens Res. 2020 Apr;43(4):271-280. doi: 10.1038/s41440-019-0373-9. Epub 2019 Dec 18.

 

24.09.2020

Andrea Bonnin Marquez

Gao et al. (2020)

„Treatment of atherosclerosis by macrophage- biomimetic nanoparticles via targeted

pharmacotherapy and sequestration of proinflammatory cytokines.“

Nat Commun. 2020 May 26;11(1):2622. doi: 10.1038/s41467-020-16439-7.

 

15.10.2020

Andrea Himmelsbach

Zhou et al. (2020)

„HDAC1-mediated deacetylation of LSD1 regulates vascular calcification by promoting autophagy in chronic renal failure.“

J Cell Mol Med. 2020 Aug;24(15):8636-8649. doi: 10.1111/jcmm.15494. Epub 2020 Jun 28.

 

22.10.2020

Christian Hemmers

Aubdool et al. (2017)

„A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage

in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure.“

Circulation. 2017 Jul 25;136(4):367-383. doi: 10.1161/CIRCULATIONAHA.117.028388. Epub 2017 Apr 26.

 

29.10.2020

Dustin Mikolajetz

Pustlauk et al. (2020)

„Induced osteogenic differentiation of human smooth muscle cells as a model of vascular calcification.“

Sci Rep. 2020 Apr 6;10(1):5951. doi: 10.1038/s41598-020-62568-w.

 

05.11.2020

Constance Baaten

Makhloufi et al. (2020)

„Assessment of Thrombotic and Bleeding Tendency in Two Mouse Models of Chronic Kidney Disease:

Adenine-Diet and 5/6th Nephrectomy.“

TH Open. 2020 Apr 16;4(2):e66-e76. doi: 10.1055/s-0040-1705138. eCollection 2020 Apr.

 

12.11.2020

Giulia Ilaria Bagarolo

Huebner et al. (2018)

„A Contemporary Conceptual Framework for Initial Data Analysis.”

Observational Studies 4 (2018) 171-192

 

19.11.2020

Hoda Alibiglou

Gao et al. (2020)

„TNAP inhibition attenuates cardiacfibrosis inducedby myocardial infarction through

deactivating TGF-β1/Smads and activating P53 signaling pathways.“

Int J Mol Sci. 2020 Mar 14;21(6):1994. doi: 10.3390/ijms21061994.

 

26.11.2020

Katja Krüger

Kahveci et al. (2020)

„Oxidative Stress and Mitochondrial AbnormalitiesContribute to Decreased Endothelial Nitric OxideSynthase Expression

and Renal Disease Progressionin Early Experimental Polycystic Kidney Disease.“

Int J Mol Sci. 2020 Mar 14;21(6):1994. doi: 10.3390/ijms21061994.

 

17.12.2020

Julia Wirth

Diwan et al. (2014)

„Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats.“

Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1169-78. doi: 10.1152/ajprenal.00676.2013. Epub 2014 Sep 10.

 

 

 

2019

10.01.2019

Shruti Bhargava

Hortells et al. (2015)

“Critical Parameters of the In Vitro Method of Vascular Smooth Muscle Cell Calcification.”

PLoS One. 2015 Nov 10;10(11):e0141751. doi: 10.1371/journal.pone.0141751. eCollection 2015.

 

14.02.2019

Bilal Mir

Sun et al. (2018)

“TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells.”

Exp Cell Res. 2018 Sep 15;370(2):478-489. doi: 10.1016/j.yexcr.2018.07.013. Epub 2018 Jul 7.

 

21.02.2019

Anika Himmelsbach

Sun et al. (2012)

“Suppression of Klotho expression by protein-bound uremic toxins is associated with

increased DNA methyltransferase expression and DNA hypermethylation.”

Kidney Int. 2012 Apr;81(7):640-50. doi: 10.1038/ki.2011.445. Epub 2012 Jan 11.

 

07.03.2019

Caroline Fabian

Kukida et al. (2019)

“AT2 receptor stimulation inhibits phosphate- induced vascular calcification.”

Kidney Int. 2019 Jan;95(1):138-148. doi: 10.1016/j.kint.2018.07.028. Epub 2018 Nov 12.

 

14.03.2019

Constance Baaten

Guo et al. (2016)

“Impact of renal impairment on platelet reactivity and clinical outcomes during chronic dual antiplatelet therapy following coronary stenting.”

Eur Heart J Cardiovasc Pharmacother. 2016 Jul;2(3):145-51. doi: 10.1093/ehjcvp/pvv052. Epub 2015 Dec 17.

 

28.03.2019

Julia Möllmann

Byrene et al. (2017)

“Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure.”

JACC Basic Transl Sci. 2017 Aug 4;2(4):347-354. doi: 10.1016/j.jacbts.2017.07.003. eCollection 2017 Aug.

 

04.04.2019

Giulia Ilaria Bagarolo

Amrhein et al. (2019)

“Scientists rise up against statistical significance.”

Nature. 2019 Mar;567(7748):305-307. doi: 10.1038/d41586-019-00857-9.

 

11.04.2019

Jana Holmar

Willy et al. (2017)

“Expanded Haemodialysis Therapy of Chronic Haemodialysis Patients Prevents Calcification

and Apoptosis of Vascular Smooth Muscle Cells in vitro.”

Blood Purif. 2018;45(1-3):131-138. doi: 10.1159/000484925. Epub 2017 Dec 22.

 

18.04.2019

Hoda Alibiglou

Jun Ma et al. (2016)

“Bioabsorbable zinc ion induced biphasic cellular responses in vascular smooth muscle cells.”

Sci Rep. 2016 Jun 1;6:26661. doi: 10.1038/srep26661.

 

25.04.2019

Miram Ommer

Slawik et al. (2018)

“Irregular pacing of ventricular cardiomyocytes induces pro-fibrotic signalling involving paracrine

effects of transforming growth factor beta and connective tissue growth factor.”

Eur J Heart Fail. 2019 Apr;21(4):482-491. doi: 10.1002/ejhf.1392. Epub 2019 Jan 24.

 

02.05.2019

Katja Krüger

Kieswich et al. (2018)

“A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain.”

BMC Nephrol. 2018 Dec 4;19(1):346. doi: 10.1186/s12882-018-1155-3.

 

09.05.2019

Eva Harlacher

Belmokhtar et al. (2016)

“Signaling of Serum Amyloid A Through Receptor for Advanced Glycation End Products

as a Possible Mechanism for Uremia-Related Atherosclerosis.”

Arterioscler Thromb Vasc Biol. 2016 May;36(5):800-9. doi: 10.1161/ATVBAHA.115.306349. Epub 2016 Mar 17.

 

16.05.2019

Julia Wirth

Leifheit- Nestler et al. (2018)

“Fibroblast growth factor 23 is induced by an activated renin-angiotensin-aldosterone system in

cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts.”

Nephrol Dial Transplant. 2018 Oct 1;33(10):1722-1734. doi: 10.1093/ndt/gfy006.

 

23.05.2019

Mareike Staudt

Ketszeri et al. (2019)

“MicroRNA-142-3p improves vascular relaxation in uremia.”

Atherosclerosis. 2019 Jan;280:28-36. doi: 10.1016/j.atherosclerosis.2018.11.024. Epub 2018 Nov 10.

 

06.06.2019

Maren Gesper

Nishiyama et al. (2019)

“Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility.”

J Cell Physiol. 2019 May;234(5):6667-6678. doi: 10.1002/jcp.27408. Epub 2018 Oct 14.

 

13.06.2019

Marieke Sternkopf

Gupta et al. (2012)

“Sitagliptin: Anti-platelet effect in diabetes and healthy volunteers.”

Platelets. 2012;23(8):565-70. doi: 10.3109/09537104.2012.721907. Epub 2012 Sep 5.

 

27.06.2019

Marina Augusto Heuschkel

Huang et al. (2019)

“SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.”

Nature. 2019 May;569(7757):565-569. doi: 10.1038/s41586-019-1140-4. Epub 2019 Apr 24.

 

11.07.2019

Pascal Mann

Osataphan et al. (2019)

“SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and - independent mechanisms.”

JCI Insight. 2019 Mar 7;4(5):e123130. doi: 10.1172/jci.insight.123130.

 

05.09.2019

Sofia de la Puente Secades

Ruisgang et al. (2017)

„Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype

of Interstitial Cells in Calcified Human Aortic Valves.“

J Am Heart Assoc. 2017 Apr 24;6(4):e005364. doi: 10.1161/JAHA.116.005364.

 

12.09.2019

Sebastian Maxeiner

Kearney et al. (2019)

„Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications.“

Blood. 2019 Mar 14;133(11):1233-1244. doi: 10.1182/blood-2018-06-856195. Epub 2018 Dec 13.

 

19.09.2019

Shruti Bhargava

Applebaum et al. (2014)

„Segregation of striated and smooth muscle lineages by a Notch-dependent regulatory network.”

BMC Biol. 2014 Jul 12;12:53. doi: 10.1186/s12915-014-0053-9.

 

26.09.2019

Rogier Veltrop

Shah et al. (2019)

„Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells.”

Cells. 2019 Jun 15;8(6):594. doi: 10.3390/cells8060594.

 

10.10.2019

Valeria Saar-Kovrov

Hu et al. (2019)

„Cyanate Induces Oxidative Stress Injury and Abnormal Lipid Metabolism in Liver through Nrf2/HO-1.”

Molecules. 2019 Sep 5;24(18):3231. doi: 10.3390/molecules24183231.

 

17.10.2019

Balram Neupane

Beyret et al. (2019)

„Single-dose CRISPR–Cas9 therapy extends lifespan of mice with Hutchinson–Gilford progeria syndrome.“

Nat Med. 2019 Mar;25(3):419-422. doi: 10.1038/s41591-019-0343-4. Epub 2019 Feb 18.

 

24.10.2019

Christian Hemmers

Landry et al. (2018)

„Ski drives an acute increase in MMP-9 gene expression and release in primary cardiac myofibroblasts.“

Physiol Rep. 2018 Nov;6(22):e13897. doi: 10.14814/phy2.13897.

 

31.10.2019

Bilal Mir

Kapustin et al. (2015)

„Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion.“

Circ Res. 2015 Apr 10;116(8):1312-23. doi: 10.1161/CIRCRESAHA.116.305012. Epub 2015 Feb 23.

 

07.11.2019

Caroline Fabian

Sanchis et al. (2019)

„Arterial “inflammaging” drives vascular calcification in children on dialysis.”

Kidney Int. 2019 Apr;95(4):958-972. doi: 10.1016/j.kint.2018.12.014. Epub 2019 Mar 1.

 

14.11.2019

Anika Himmelsbach

Zhu et al. (2016)

“A novel role for the mineralocorticoid receptor in glucocorticoid driven vascular calcification.”

Vascul Pharmacol. 2016 Nov;86:87-93.doi: 10.1016/j.vph.2016.04.005. Epub 2016 May 3.

 

Tatsumoto et al. (2015)

“Spironolactone ameliorates arterial medial calcification in uremic rats:

the role of mineralocorticoid receptor signaling in vascular calcification.”

Am J Physiol Renal Physiol. 2015 Dec 1;309(11):F967-79. doi: 10.1152/ajprenal.00669.2014. Epub 2015 Sep 2

 

 

21.11.2019

Constance Baaten

Zhu et al. (2016)

“Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk”

Cell. 2016 Mar 24;165(1):111-124. doi: 10.1016/j.cell.2016.02.011. Epub 2016 Mar 10.

 

28.11.2019

Eva Harlacher

Winterberg et al. (2019)

“T Cells Play a Causal Role in Diastolic Dysfunction during Uremic Cardiomyopathy.”

J Am Soc Nephrol. 2019 Feb 6;30(3):407-420. doi: 10.1681/ASN.2017101138. Online ahead of print.

 

12.12.2019

Guzide Bender

Fotakis et al. (2019)

“Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate

Over Proinflammatory Effects in Atherosclerotic Plaques.”

Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):e253-e272. doi: 10.1161/ATVBAHA.119.313253. Epub 2019 Oct 3.

 

19.12.2019

Hoda Alibiglou

Tziakas et al. (2019)

“Lysed Erythrocyte Membranes Promote Vascular Calcification.”

Circulation. 2019 Apr 23;139(17):2032-2048. doi: 10.1161/CIRCULATIONAHA.118.037166.

 

 

 

2018

 

14.05.2018

Astrid Artmeyer

Emmens at al. (2017)

„Proteomic diversity of high-density lipoprotein explains its association with clinical outcome in patients with heart failure.“

Eur J Heart Fail. 2018 Feb;20(2):260-267. doi: 10.1002/ejhf.1101. Epub 2017 Dec 18.

 

24.05.2018

Anika Himmelsbach

Tsai et al. (2017)

„Anomalous baroreflex functionality inherent in floxed and Cre-Lox mice: an overlooked physiological phenotype.“

Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H700-H707. doi: 10.1152/ajpheart.00346.2017. Epub 2017 Aug 4.

 

Zomer at al. (2015)

„In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior.”

Cell. 2015 May 21;161(5):1046-1057. doi: 10.1016/j.cell.2015.04.042.

 

07.06.2018

Bilal Mir

Camargo et al. (2018)

“Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation,

and Endoplasmic Reticulum Stress Response in Hypertension.”

Hypertension. 2018 Jul;72(1):235-246. doi: 10.1161/HYPERTENSIONAHA.118.10824. Epub 2018 May 29.

 

21.06.2018

Christian Hemmers

Brinck et al. (2018)

“High-density lipoprotein from end-stage renal disease patients exhibits superior

cardioprotection and increase in sphingosine-1- phosphate.”

Eur J Clin Invest. 2018 Feb;48(2). doi: 10.1111/eci.12866. Epub 2017 Dec 14.

 

16.08.2018

Corinna Schulte

Wang et al. (2007)

“Protein carbamylation links inflammation, smoking, uremia and atherogenesis.”

Nat Med. 2007 Oct;13(10):1176-84. doi: 10.1038/nm1637. Epub 2007 Sep 9.

 

30.08.2018

Eva Harlacher

Saum et al. (2018)

“Uremic Advanced Glycation End Products and Protein-Bound Solutes Induce Endothelial

Dysfunction Through Suppression of Krüppel-Like Factor 2.”

J Am Heart Assoc. 2018 Jan 4;7(1): e007566. doi: 10.1161/JAHA.117.007566.

 

13.09.2018

Jana Holmar

Frauscher at al. (2018)

“Autophagy Protects From Uremic Vascular Media calcification.”

Front Immunol. 2018 Aug 14;9:1866. Doi: 10.3389/fimmu.2018.01866. eCollection 2018.

 

20.09.2018

Josefin Soppert

Feng et al. (2017)

“Advanced oxidation protein products aggravate cardiac remodeling via cardiomyocyte apoptosis in chronic kidney disease”

Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H475-H483. Doi: 10.1152/ajpheart.00628.2016. Epub 2017 Nov 3.

 

04.10.2018

Katja Krüger

Wang et al. (2018)

“Dietary supplementation with ketoacids protects against CKD-induced oxidative damage and

mitochondrial dysfunction in skeletal muscle of 5/6 nephrectomised rats.”

Skelet Muscle. 2018 May 31;8(1):18. Doi: 10.1186/s13395-018-0164-z.

 

11.10.2018

Julia Wirth

Yang et al. (2015)

“Indoxyl sulfate induces oxidative stress and hypertrophy in cardiomyocytes by inhibiting the AMPK/UCP2 signaling pathway.”

Toxicol Lett. 2015 Apr 16;234(2):110-9. Doi: 10.1016/j.toxlet.2015.01.021. Epub 2015 Feb 19.

 

08.11.2018

Maren Gesper

Suez et al. (2014)

“Artificial sweeteners induce glucose intolerance by altering the gut microbiota.”

Nature. 2014 Oct 9;514(7521):181-6. Doi: 10.1038/nature13793. Epub 2014 Sep 17.

 

15.11.2018

Mareike Staudt

Shang et al. (2017)

“MicroRNA-92a mediates endothelial dysfunction in CKD.”

Am Soc Nephrol. 2017 Nov;28(11):3251-3261. Doi: 10.1681/ASN.2016111215. Epub 2017 Jul 10.

 

22.11.2018

Marina Augusto Heuschkel

Hamczyk et al. (2018)

“Vascular Smooth Muscle–Specific Progerin Expression Accelerates Atherosclerosis and

Death in a Mouse Model of Hutchinson- Gilford Progeria Syndrome.”

Circulation. 2018 Jul 17;138(3):266-282. Doi: 10.1161/CIRCULATIONAHA.117.030856. Epub 2018 Feb 28.

 

06.12.2018

Mihaela Rusu

Asgari et al. (2017)

“In vitro fibrillogenesis of tropocollagen type III in collagen type I affects its relative fibrillar topology and mechanics.”

Sci Rep. 2017 May 3;7(1):1392. doi: 10.1038/s41598-017-01476-y.

 

13.12.2018

Pascal Mann

Temple et al. (2018)

“Fat, Sugar, Whole Grains and Heart Disease: 50 Years of Confusion.”

Nutrients. 2018 Jan 4;10(1):39. doi: 10.3390/nu10010039.

 

20.12.2018

Sebastian Maxeiner

Tian et al. (2013)

“High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.”

Nature. 2013 Jul 18;499(7458):346-9. doi: 10.1038/nature12234. Epub 2013 Jun 19.

 

Ruby et al. (2018)

“Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age.”

Elife. 2018 Jan 24;7:e31157. doi: 10.7554/eLife.31157.

 

Park et al. (2017)

“Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.”

Science. 2017 Apr 21;356(6335):307-311. doi: 10.1126/science.aab3896.

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