IRTG Journal Club

2021

21.01.2021

Linsey Peters

"EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis."

Circulation. 2017 Aug 8;136(6):566-582. doi: 10.1161/CIRCULATIONAHA.116.026644. Epub 2017 May 9.

 

28.01.2021

Maren Gesper

"Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis.“

Lab Invest. 2019 Mar;99(3):346-357. doi: 10.1038/s41374-018-0091-y. Epub 2018 Aug 1.

 

18.02.2021

Maria Chiara Arrivas

"Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells.“

Nat Med. 2019 Nov;25(11):1761-1771. doi: 10.1038/s41591-019-0633-x. Epub 2019 Nov 7.

 

25.02.2021

Sophie Kathrin Schiestel

"Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.“

Cell Metab. 2017 Oct 3;26(4):672-685.e4. doi: 10.1016/j.cmet.2017.08.019. Epub 2017 Sep 14.

 

04.03.2021

Marina Augusto Heuschkel

"Warfarin Accelerates Medial Arterial Calcification in Humans.”

Arterioscler Thromb Vasc Biol. 2020 May;40(5):1413-1419. doi: 10.1161/ATVBAHA.119.313879. Epub 2020 Feb 13.

 

11.03.2021

Michaela Lellig

"Alarmone Ap4A is elevated by aminoglycosideantibiotics and enhances their bactericidal activity.“

Proc Natl Acad Sci USA. 2019 May 7;116(19):9578-9585. doi: 10.1073/pnas.1822026116. Epub 2019 Apr 19.

 

18.03.2021

Pascal Mann

"Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.

Cell. 2016 Sep 8;166(6):1512-1525.e12. doi: 10.1016/j.cell.2016.07.026.

2020

16.01.2020

Josefin Soppert

“Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice.”

J Lipid Res. 2020 Mar;61(3):365-375. doi: 10.1194/jlr.RA119000419. Epub 2019 Dec 16.

 

23.01.2020

Pascal Mann

“Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.”

Cardiovasc Res. 2019 Sep 1;115(11):1606-1616. doi: 10.1093/cvr/cvz045.

 

30.01.2020

Julia Wirth

“Endothelial cell modulation of cardiomyocyte gene expression.”

Exp Cell Res. 2019 Oct 15;383(2):111565. doi: 10.1016/j.yexcr.2019.111565. Epub 2019 Aug 20.

 

13.02.2020

Kabita Pradhan

“Cardiomyocyte Derived miR-328 Promotes Cardiac Fibrosis by Paracrinely Regulating Adjacent Fibroblasts.”

Cell Physiol Biochem. 2018;46(4):1555-1565. doi: 10.1159/000489201. Epub 2018 Apr 19.

 

27.02.2020

Katja Krüger

“Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress.”

Sci Adv. 2019 Sep 11;5(9):eaax1978. doi: 10.1126/sciadv.aax1978. eCollection 2019 Sep.

 

05.03.2020

Linsey Peters

“A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.”

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20446-51. doi: 10.1073/pnas.0810372105. Epub 2008 Dec 11

 

 

07.05.2020

Mareike Staudt

"Laboratory mice born to wild mice have natural microbiota and model human immune responses.”

Science. 2019 Aug 2;365(6452):eaaw4361. doi: 10.1126/science.aaw4361. Epub 2019 Aug 1.

 

14.05.2020

Marina Augusto Heuschkel

“Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals.”

Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):751-765. doi: 10.1161/ATVBAHA.119.313414. Epub 2020 Jan 16.

 

28.05.2020

Maria Chiara Arrivas

“Sleep modulates haematopoiesis and protects against atherosclerosis.”

Nature. 2019 Feb;566(7744):383-387. doi: 10.1038/s41586-019-0948-2. Epub 2019 Feb 13.

 

04.06.2020

Maren Gesper

“Loss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair.”

Circulation. 2019 Jan 29;139(5):647-659. doi: 10.1161/CIRCULATIONAHA.118.035235.

 

18.06.2020

Pascal Mann

“SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease.”

Nat Commun. 2020 May 1;11(1):2127. doi: 10.1038/s41467-020-15983-6.

 

13.08.2020

Sofia de la Puente Secades

„Sclerostin as Regulatory Molecule in Vascular Media Calcification and the Bone–Vascular Axis.“

Toxins (Basel). 2019 Jul 21;11(7):428. doi: 10.3390/toxins11070428.

 

20.08.2020

Sebastian Maxeiner

„Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs.“

Nat Commun. 2020 Aug 4;11(1):3890. doi: 10.1038/s41467-020-17648-w.

 

27.08.2020

Shruti Bhargava

„Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the

Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis.“

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1878-1889. doi: 10.1161/ATVBAHA.118.311238.

 

03.09.2020

Sai Sahana Sundararaman

„A novel function of calcium sensing receptor in chronic hypoxia- induced pulmonary venous smooth muscle cells proliferation.“

Hypertens Res. 2020 Apr;43(4):271-280. doi: 10.1038/s41440-019-0373-9. Epub 2019 Dec 18.

 

24.09.2020

Andrea Bonnin Marquez

„Treatment of atherosclerosis by macrophage- biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines.“

Nat Commun. 2020 May 26;11(1):2622. doi: 10.1038/s41467-020-16439-7.

 

15.10.2020

Andrea Himmelsbach

„HDAC1-mediated deacetylation of LSD1 regulates vascular calcification by promoting autophagy in chronic renal failure.“

J Cell Mol Med. 2020 Aug;24(15):8636-8649. doi: 10.1111/jcmm.15494. Epub 2020 Jun 28.

 

22.10.2020

Christian Hemmers

"A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension,

Cardiac Hypertrophy, and Heart Failure.“

Circulation. 2017 Jul 25;136(4):367-383. doi: 10.1161/CIRCULATIONAHA.117.028388. Epub 2017 Apr 26.

 

29.10.2020

Dustin Mikolajetz

"Induced osteogenic differentiation of human smooth muscle cells as a model of vascular calcification.“

Sci Rep. 2020 Apr 6;10(1):5951. doi: 10.1038/s41598-020-62568-w.

 

05.11.2020

Constance Baaten

"Assessment of Thrombotic and Bleeding Tendency in Two Mouse Models of Chronic Kidney Disease: Adenine-Diet and 5/6th Nephrectomy.“

TH Open. 2020 Apr 16;4(2):e66-e76. doi: 10.1055/s-0040-1705138. eCollection 2020 Apr.

 

12.11.2020

Giulia Ilaria Bagarolo

"A Contemporary Conceptual Framework for Initial Data Analysis.”

Observational Studies 4 (2018) 171-192

 

19.11.2020

Hoda Alibiglou

"TNAP inhibition attenuates cardiacfibrosis inducedby myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways.“

Int J Mol Sci. 2020 Mar 14;21(6):1994. doi: 10.3390/ijms21061994.

 

26.11.2020

Katja Krüger

"Oxidative Stress and Mitochondrial AbnormalitiesContribute to Decreased Endothelial Nitric OxideSynthase Expression and

Renal Disease Progressionin Early Experimental Polycystic Kidney Disease.“

Int J Mol Sci. 2020 Mar 14;21(6):1994. doi: 10.3390/ijms21061994.

 

17.12.2020

Julia Wirth

"Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats.“

Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1169-78. doi: 10.1152/ajprenal.00676.2013. Epub 2014 Sep 10.

 

 

 

2019

10.01.2019

Shruti Bhargava

“Critical Parameters of the In Vitro Method of Vascular Smooth Muscle Cell Calcification.”

PLoS One. 2015 Nov 10;10(11):e0141751. doi: 10.1371/journal.pone.0141751. eCollection 2015.

 

14.02.2019

Bilal Mir

“TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells.”

Exp Cell Res. 2018 Sep 15;370(2):478-489. doi: 10.1016/j.yexcr.2018.07.013. Epub 2018 Jul 7.

 

21.02.2019

Anika Himmelsbach

“Suppression of Klotho expression by protein-bound uremic toxins is associated with

increased DNA methyltransferase expression and DNA hypermethylation.”

Kidney Int. 2012 Apr;81(7):640-50. doi: 10.1038/ki.2011.445. Epub 2012 Jan 11.

 

 

07.03.2019

Sofia de la Puente Secades

“AT2 receptor stimulation inhibits phosphate- induced vascular calcification.”

Kidney Int. 2019 Jan;95(1):138-148. doi: 10.1016/j.kint.2018.07.028. Epub 2018 Nov 12.

 

14.03.2019

Constance Baaten

“Impact of renal impairment on platelet reactivity and clinical outcomes during chronic dual antiplatelet therapy following coronary stenting.”

Eur Heart J Cardiovasc Pharmacother. 2016 Jul;2(3):145-51. doi: 10.1093/ehjcvp/pvv052. Epub 2015 Dec 17.

 

28.03.2019

Julia Möllmann

“Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure.”

JACC Basic Transl Sci. 2017 Aug 4;2(4):347-354. doi: 10.1016/j.jacbts.2017.07.003. eCollection 2017 Aug.

 

04.04.2019

Giulia Ilaria Bagarolo

“Scientists rise up against statistical significance.”

Nature. 2019 Mar;567(7748):305-307. doi: 10.1038/d41586-019-00857-9.

11.04.2019

Jana Holmar

“Expanded Haemodialysis Therapy of Chronic Haemodialysis Patients Prevents Calcification and Apoptosis of Vascular Smooth Muscle Cells in vitro.”

Blood Purif. 2018;45(1-3):131-138. doi: 10.1159/000484925. Epub 2017 Dec 22.

 

18.04.2019

Hoda Alibiglou

“Bioabsorbable zinc ion induced biphasic cellular responses in vascular smooth muscle cells.”

Sci Rep. 2016 Jun 1;6:26661. doi: 10.1038/srep26661.

 

25.04.2019

Miram Ommer

“Irregular pacing of ventricular cardiomyocytes induces pro-fibrotic signalling involving paracrine effects

of transforming growth factor beta and connective tissue growth factor.”

Eur J Heart Fail. 2019 Apr;21(4):482-491. doi: 10.1002/ejhf.1392. Epub 2019 Jan 24.

 

02.05.2019

Katja Krüger

“A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain.”

BMC Nephrol. 2018 Dec 4;19(1):346. doi: 10.1186/s12882-018-1155-3.

 

09.05.2019

Eva Harlacher

“Signaling of Serum Amyloid A Through Receptor for Advanced Glycation End Products as a Possible Mechanism for Uremia-Related Atherosclerosis.”

Arterioscler Thromb Vasc Biol. 2016 May;36(5):800-9. doi: 10.1161/ATVBAHA.115.306349. Epub 2016 Mar 17.

 

16.05.2019

Julia Wirth

“Fibroblast growth factor 23 is induced by an activated renin-angiotensin-aldosterone system in cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts.”

Nephrol Dial Transplant. 2018 Oct 1;33(10):1722-1734. doi: 10.1093/ndt/gfy006.

 

23.05.2019

Mareike Staudt

“MicroRNA-142-3p improves vascular relaxation in uremia.”

Atherosclerosis. 2019 Jan;280:28-36. doi: 10.1016/j.atherosclerosis.2018.11.024. Epub 2018 Nov 10.

 

06.06.2019

Maren Gesper

“Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility.”

J Cell Physiol. 2019 May;234(5):6667-6678. doi: 10.1002/jcp.27408. Epub 2018 Oct 14.

 

13.06.2019

Marieke Sternkopf

“Sitagliptin: Anti-platelet effect in diabetes and healthy volunteers.”

Platelets. 2012;23(8):565-70. doi: 10.3109/09537104.2012.721907. Epub 2012 Sep 5.

 

27.06.2019

Marina Augusto Heuschkel

“SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.”

Nature. 2019 May;569(7757):565-569. doi: 10.1038/s41586-019-1140-4. Epub 2019 Apr 24.

 

11.07.2019

Pascal Mann

“SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and - independent mechanisms.”

JCI Insight. 2019 Mar 7;4(5):e123130. doi: 10.1172/jci.insight.123130.

 

05.09.2019

Sofia de la Puente Secades

"Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves.“

J Am Heart Assoc. 2017 Apr 24;6(4):e005364. doi: 10.1161/JAHA.116.005364.

 

12.09.2019

Sebastian Maxeiner

"Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications.“

Blood. 2019 Mar 14;133(11):1233-1244. doi: 10.1182/blood-2018-06-856195. Epub 2018 Dec 13.

 

19.09.2019

Shruti Bhargava

"Segregation of striated and smooth muscle lineages by a Notch-dependent regulatory network.”

BMC Biol. 2014 Jul 12;12:53. doi: 10.1186/s12915-014-0053-9.

 

26.09.2019

Rogier Veltrop

"Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells.”

Cells. 2019 Jun 15;8(6):594. doi: 10.3390/cells8060594.

 

10.10.2019

Valeria Saar-Kovrov

"Cyanate Induces Oxidative Stress Injury and Abnormal Lipid Metabolism in Liver through Nrf2/HO-1.”

Molecules. 2019 Sep 5;24(18):3231. doi: 10.3390/molecules24183231.

 

17.10.2019

Balram Neupane

"Single-dose CRISPR–Cas9 therapy extends lifespan of mice with Hutchinson–Gilford progeria syndrome.“

Nat Med. 2019 Mar;25(3):419-422. doi: 10.1038/s41591-019-0343-4. Epub 2019 Feb 18.

 

24.10.2019

Christian Hemmers

"Ski drives an acute increase in MMP-9 gene expression and release in primary cardiac myofibroblasts.“

Physiol Rep. 2018 Nov;6(22):e13897. doi: 10.14814/phy2.13897.

31.10.2019

Bilal Mir

"Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion.“

Circ Res. 2015 Apr 10;116(8):1312-23. doi: 10.1161/CIRCRESAHA.116.305012. Epub 2015 Feb 23.

 

07.11.2019

Caroline Fabian

"Arterial “inflammaging” drives vascular calcification in children on dialysis.”

Kidney Int. 2019 Apr;95(4):958-972. doi: 10.1016/j.kint.2018.12.014. Epub 2019 Mar 1.

 

14.11.2019

Anika Himmelsbach

“A novel role for the mineralocorticoid receptor in glucocorticoid driven vascular calcification.”

Vascul Pharmacol. 2016 Nov;86:87-93.doi: 10.1016/j.vph.2016.04.005. Epub 2016 May 3.

 

“Spironolactone ameliorates arterial medial calcification in uremic rats: the role of mineralocorticoid receptor signaling in vascular calcification.”

Am J Physiol Renal Physiol. 2015 Dec 1;309(11):F967-79. doi: 10.1152/ajprenal.00669.2014. Epub 2015 Sep 2

21.11.2019

Constance Baaten

“Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk”

Cell. 2016 Mar 24;165(1):111-124. doi: 10.1016/j.cell.2016.02.011. Epub 2016 Mar 10.

 

28.11.2019

Eva Harlacher

“T Cells Play a Causal Role in Diastolic Dysfunction during Uremic Cardiomyopathy.”

J Am Soc Nephrol. 2019 Feb 6;30(3):407-420. doi: 10.1681/ASN.2017101138. Online ahead of print.

 

12.12.2019

Guzide Bender

“Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques.”

Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):e253-e272. doi: 10.1161/ATVBAHA.119.313253. Epub 2019 Oct 3.

 

19.12.2019

Hoda Alibiglou

“Lysed Erythrocyte Membranes Promote Vascular Calcification.”

Circulation. 2019 Apr 23;139(17):2032-2048. doi: 10.1161/CIRCULATIONAHA.118.037166.

 

 

2018

14.05.2018

Astrid Artmeyer

"Proteomic diversity of high-density lipoprotein explains its association with clinical outcome in patients with heart failure.“

Eur J Heart Fail. 2018 Feb;20(2):260-267. doi: 10.1002/ejhf.1101. Epub 2017 Dec 18.

 

24.05.2018

Anika Himmelsbach

"Anomalous baroreflex functionality inherent in floxed and Cre-Lox mice: an overlooked physiological phenotype.“

Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H700-H707. doi: 10.1152/ajpheart.00346.2017. Epub 2017 Aug 4.

 

"In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior.”

Cell. 2015 May 21;161(5):1046-1057. doi: 10.1016/j.cell.2015.04.042.

 

07.06.2018

Bilal Mir

“Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in Hypertension.”

Hypertension. 2018 Jul;72(1):235-246. doi: 10.1161/HYPERTENSIONAHA.118.10824. Epub 2018 May 29.

 

21.06.2018

Christian Hemmers

“High-density lipoprotein from end-stage renal disease patients exhibits superior cardioprotection and increase in sphingosine-1- phosphate.”

Eur J Clin Invest. 2018 Feb;48(2). doi: 10.1111/eci.12866. Epub 2017 Dec 14.

 

16.08.2018

Corinna Schulte

“Protein carbamylation links inflammation, smoking, uremia and atherogenesis.”

Nat Med. 2007 Oct;13(10):1176-84. doi: 10.1038/nm1637. Epub 2007 Sep 9.

 

30.08.2018

Eva Harlacher

“Uremic Advanced Glycation End Products and Protein-Bound Solutes Induce Endothelial Dysfunction Through Suppression of Krüppel-Like Factor 2.”

J Am Heart Assoc. 2018 Jan 4;7(1): e007566. doi: 10.1161/JAHA.117.007566.

 

13.09.2018

Jana Holmar

“Autophagy Protects From Uremic Vascular Media calcification.”

Front Immunol. 2018 Aug 14;9:1866. Doi: 10.3389/fimmu.2018.01866. eCollection 2018.

 

20.09.2018

Josefin Soppert

“Advanced oxidation protein products aggravate cardiac remodeling via cardiomyocyte apoptosis in chronic kidney disease”

Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H475-H483. Doi: 10.1152/ajpheart.00628.2016. Epub 2017 Nov 3.

 

04.10.2018

Katja Krüger

“Dietary supplementation with ketoacids protects against CKD-induced oxidative damage and

mitochondrial dysfunction in skeletal muscle of 5/6 nephrectomised rats.”

Skelet Muscle. 2018 May 31;8(1):18. Doi: 10.1186/s13395-018-0164-z.

 

11.10.2018

Julia Wirth

“Indoxyl sulfate induces oxidative stress and hypertrophy in cardiomyocytes by inhibiting the AMPK/UCP2 signaling pathway.”

Toxicol Lett. 2015 Apr 16;234(2):110-9. Doi: 10.1016/j.toxlet.2015.01.021. Epub 2015 Feb 19.

 

08.11.2018

Maren Gesper

“Artificial sweeteners induce glucose intolerance by altering the gut microbiota.”

Nature. 2014 Oct 9;514(7521):181-6. Doi: 10.1038/nature13793. Epub 2014 Sep 17.

 

15.11.2018

Mareike Staudt

“MicroRNA-92a mediates endothelial dysfunction in CKD.”

Am Soc Nephrol. 2017 Nov;28(11):3251-3261. Doi: 10.1681/ASN.2016111215. Epub 2017 Jul 10.

 

22.11.2018

Marina Augusto Heuschkel

“Vascular Smooth Muscle–Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson- Gilford Progeria Syndrome.”

Circulation. 2018 Jul 17;138(3):266-282. Doi: 10.1161/CIRCULATIONAHA.117.030856. Epub 2018 Feb 28.

 

06.12.2018

Mihaela Rusu

“In vitro fibrillogenesis of tropocollagen type III in collagen type I affects its relative fibrillar topology and mechanics.”

Sci Rep. 2017 May 3;7(1):1392. doi: 10.1038/s41598-017-01476-y.

13.12.2018

Pascal Mann

“Fat, Sugar, Whole Grains and Heart Disease: 50 Years of Confusion.”

Nutrients. 2018 Jan 4;10(1):39. doi: 10.3390/nu10010039.

 

20.12.2018

Sebastian Maxeiner

“High-molecular-mass hyaluronan mediates thecancer resistance of the naked mole rat.”

Nature. 2013 Jul 18;499(7458):346-9. doi: 10.1038/nature12234. Epub 2013 Jun 19.

 

“Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age.”

Elife. 2018 Jan 24;7:e31157. doi: 10.7554/eLife.31157.

 

“Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.”

Science. 2017 Apr 21;356(6335):307-311. doi: 10.1126/science.aab3896.

.