Dr. Heidi Noels and Dr. Yvonne Döring receive the W.H. Hauss Award from the DGAF
19-21 April 2018
Dr. Heidi Noels from the Institute for Molecular Cardiovascular Research at RWTH Aachen University together with Dr. Yvonne Döring from the Institute for Prophylaxis and Epidemiology of Circulatory Diseases at LMU Munich together received the DGAF W.H. Hauss Award 2018 from the German Society for Atherosclerosis Research (DGAF) during the 32nd Annual Meeting of the DGAF in Rauischholzhausen, Germany. They were awarded for their publication "Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies." (Circulation. 2017; 136: 388-403). In this work it could be shown that vascular CXCR4 has an atheroprotective function by maintaining the arterial integrity and preserving the endothelial barrier function. In addition, CXCR4 stabilizes a contractile smooth muscle cell phenotype. Targeted enhancement of these CXCR4-mediated protective functions could open up novel therapeutic options in the treatment of atherosclerosis.
The award was sponsored by a long-standing active member of the DGAF, Prof. Dr. Winfried März.
Project area Z
Administrative project
Robert Werner Mertens
MD student
University Hospital RWTH Aachen
Department of Internal Medicine
Project: The role of incretin hormone GLP-2 in septic cardiomyopathy
PI: Michael Lehrke
Robert Werner Mertens
MD student
University Hospital RWTH Aachen
Department of Internal Medicine
Project: The role of incretin hormone GLP-2 in septic cardiomyopathy
PI: Michael Lehrke
Consortium
Mechanisms of Cardiovascular Complications
in Chronic Kidney Disease
The SFB/TRR219 is supported by the German Research Foundation (DFG)
Project-ID 322900939
IRTG Journal Club
2023
19.01.2023
Julia Wollenhaupt
Soranno et al. (2022)
“Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia–reperfusion acute kidney injury.”
Sci Rep. 2022 Jan 12;12(1):643.doi: 10.1038/s41598-021-04701-x.
09.02.2023
Leonida Rakateli
Snarski et al. (2022)
“Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice.”
Arterioscler Thromb Vasc Biol. 2022 Feb;42(2):113-126. doi: 10.1161/ATVBAHA.121.316090. Epub 2021 Dec 2.
16.02.2023
Li Zhang
Tombor et al. (2021)
“Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction.”
Nat Commun. 2021 Jan 29;12(1):681.doi: 10.1038/s41467-021-20905-1.
02.03.2023
Nicolas Hense
Zhai et al. (2022)
“Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis.”
Nat Commun. 2022 Dec 6;13(1):7500.doi: 10.1038/s41467-022-35330-1.
16.03.2023
Rosanna Huchzermeier
He et al. (2023)
“Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and
enhanced macrophage-targeted drug delivery.”
Bioact Mater. 2022 Apr 7;19:115-126.doi: 10.1016/j.bioactmat.2022.03.041. eCollection 2023 Jan.
30.03.2023
Michaela Lellig
Tain et al. (2023)
“Dietary Resveratrol Butyrate Monoester Supplement Improves Hypertension and
Kidney Dysfunction in a Young Rat Chronic Kidney Disease Model.”
Nutrients. 2023 Jan 26;15(3):635.doi: 10.3390/nu15030635.
04.05.2023
Sonja Vondenhoff
Schunk et al. (2021)
“Interleukin-1α Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease.”
Circulation. 2021 Sep 14;144(11):893-908. doi: 10.1161/CIRCULATIONAHA.121.053547. Epub 2021 Jul 1.
25.05.2023
Tianyu Xia
Florens et al. (2023)
“Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes.”
Circulation. 2023 Feb 28;147(9):746-758. doi: 10.1161/CIRCULATIONAHA.122.063014. Epub 2023 Jan 25.
15.06.2023
Tim Caspers
Li Li et al. (2023)
“Proteomic landscape of the extracellular matrix in the fibrotic kidney.”
Kidney Int. 2023 Jun;103(6):1063-1076. doi: 10.1016/j.kint.2023.01.021. Epub 2023 Feb 17.
29.06.2023
Sanne Maas
Janssen et al. (2023)
“Monocytes re-enter the bone marrow during fasting and alter the host response to infection.”
Immunity. 2023 Apr 11;56(4):783-796.e7. doi: 10.1016/j.immuni.2023.01.024. Epub 2023 Feb 23.
31.08.2023
Naresh Ganesh
Zhao et al. (2023)
“Heart–gut microbiota communication determines the severity of cardiac injury after myocardial ischaemia/reperfusion.”
Cardiovasc Res. 2023 Jun 13;119(6):1390-1402. doi: 10.1093/cvr/cvad023.
21.09.2023
Sofia De la Puente Secades
Shoji et al. (2021)
„Comparative Effects of Etelcalcetide and Maxacalcitol on Serum Calcification Propensity in Secondary
Hyperparathyroidism: A Randomized Clinical Trial.”
Clin J Am Soc Nephrol. 2021 Apr 7;16(4):599-612.
12.10.2023
Shruti Bhargava
Chen et al. (2022)
“Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome.”
Nat Med. 2022 Nov;28(11):2333-2343. doi: 10.1038/s41591-022-02014-8. Epub 2022 Oct 10.
26.10.2023
Xiyang Liu
Goldspink et al. (2023)
“Kidney medullary sodium chloride concentrations induce neutrophil and monocyte extracellular
DNA traps that defend against pyelonephritis in vivo.”
Kidney Int. 2023 Aug;104(2):279-292. doi: 10.1016/j.kint.2023.03.034. Epub 2023 Apr 23.
02.11.2023
Burcu Yesilyurt
Shi et al. (2022)
“Oxidative phosphorylation promotes vascular calcification in chronic kidney disease.”
Cell Death Dis. 2022 Mar 11;13(3):229. doi: 10.1038/s41419-022-04679-y.
16.11.2023
Yingying Gao
Melica et al. (2022)
“Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice.”
Sci Transl Med. 2022 Aug 10;14(657):eabg3277. doi: 10.1126/scitranslmed.abg3277. Epub 2022 Aug 10.
30.11.2023
Zhuangting Rao
Li et al. (2022)
“An exercise-inducible metabolite that suppresses feeding and obesity.”
Nature. 2022 Jun;606(7915):785-790. doi: 10.1038/s41586-022-04828-5. Epub 2022 Jun 15.
14.12.2023
Zhuojun Wu
Amaya- Garrido et al. (2023)
“Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease.”
Sci Transl Med. 2023 Sep 6;15(712):eabn5939.
2022
27.01.2022
Sai Sahana Sundararaman
Wang et al. (2021)
“Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications.”
Theranostics. 2021 Jan 1;11(1):164-180.doi: 10.7150/thno.47841.eCollection 2021.
03.02.2022
Sanne Lidewij Maas
Zhang et al. (2019)
“Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers.”
Nat Commun. 2019 Sep 3;10(1):3974.doi: 10.1038/s41467-019-11911-5.
10.02.2022
Sofia De la Puente Secades
Chen et al. (2021)
“Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation.”
FEBS J. 2021 Nov 23.doi: 10.1111/febs.16291.Online ahead of print.
17.02.2022
Valeria Saar-Kovrov
Gaul et al. (2021)
“Extracellular NLRP3 inflammasome particles are internalized by human coronary artery smooth muscle cells
and induce pro-atherogenic effects.”
Sci Rep. 2021 Jul 26;11(1):15156.doi: 10.1038/s41598-021-94314-1.
10.03.2022
Vytautas Kucikas
De Kort et al. (2021)
“Inflammatory and regenerative processes in bioresorbable synthetic pulmonary valves
up to two years in sheep–Spatiotemporal insights augmented by Raman microspectroscopy.”
Acta Biomater. 2021 Nov;135:243-259. doi: 10.1016/j.actbio.2021.09.005. Epub 2021 Sep 10.
31.03.2022
Setareh Orth-Alampour
Speer et al. (2014)
“Carbamylated low-density lipoprotein induces endothelial dysfunction.”
Eur Heart J. 2014 Nov 14;35(43):3021-32. doi: 10.1093/eurheartj/ehu111. Epub 2014 Mar 21.
07.04.2022
Shruti Bhargava
Freise et al. (2021)
“Uraemic extracellular vesicles augment osteogenic transdifferentiation of
vascular smooth muscle cells via enhanced AKT signalling and PiT-1 expression.”
J Cell Mol Med. 2021 Jun;25(12):5602-5614. doi: 10.1111/jcmm.16572. Epub 2021 May 7.
21.04.2022
Zhoujun Wu
Nakano et al. (2019)
“Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling.”
Circulation. 2019 Jan 2;139(1):78-96. doi: 10.1161/CIRCULATIONAHA.118.034588.
19.05.2022
Alexandra Kindelan Lohse
Kaschina et al. (2008)
“Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with
the renin-angiotensin system in myocardial infarction?.”
Circulation. 2008 Dec 9;118(24):2523-32. doi:10.1161/CIRCULATIONAHA.108.784868. Epub 2008 Nov 24.
09.06.2022
Andrea Bonnin-Marquez
Busnelli et al. (2022)
“Lack of ApoA-I in ApoEKO Mice Causes Skin Xanthomas, Worsening of Inflammation,
and Increased Coronary Atherosclerosis in the Absence of Hyperlipidemia.”
Arterioscler Thromb Vasc Biol. 2022 May 19;101161ATVBAHA122317790. doi: 10.1161/ATVBAHA.122.317790. Online ahead of print.
23.06.2022
Constance Baaten
Kaiser et al. (2022)
“Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI.”
Blood. 2022 Apr 26;blood.2021014914. doi: 10.1182/blood.2021014914. Online ahead of print.
07.07.2022
Dustin Mikolajetz
Bogdanova et al. (2019)
“Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties.”
Sci Rep. 2019 Sep 10;9(1):12934. doi: 10.1038/s41598-019-49016-0.
14.07.2022
Corinna Schulte
Lin et al. (2022)
“TREM‐2 mediates dendritic cell–induced NO to suppress Th17 activation and ameliorate chronic kidney diseases.”
J Mol Med (Berl). 2022 Jun;100(6):917-931. doi: 10.1007/s00109-022-02201-7. Epub 2022 May 9.
15.09.2022
Melina Stein
Di Pietro et al. (2022)
“Targeting the ASMase/S1P pathway protects from sortilin - evoked vascular damage in hypertension.”
J Clin Invest. 2022 Feb 1;132(3):e146343. doi: 10.1172/JCI146343.
29.09.2022
Erik Merckelbach
Lim et al. (2020)
“Activation of β-catenin by TGF-β1 promotes ligament-fibroblastic differentiation and inhibits cementoblastic differentiation of human periodontal ligament cells.”
Stem Cells. 2020 Sep 15.doi: 10.1002/stem.3275.
13.10.2022
Josefin Soppert
Lim et al. (2020)
“Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction.”
Microbiome. 2018 Apr 3;6(1):66.doi: 10.1186/s40168-018-0441-4.
3.11.2022
Giulia Ilaria Bagarolo
He et al. (2021)
“Urinary peptides in heart failure: a link to molecular pathophysiology.”
Eur J Heart Fail. 2021 Nov;23(11):1875-1887.doi: 10.1002/ejhf.2195.Epub 2021 May 7.
24.11.2022
Lea Herkens
Chang et al. (2022)
“Angiopoietin-2 inhibition attenuates kidney fibrosis by hindering chemokine C-C motif ligand 2 expression and apoptosis of endothelial cells.
Kidney Int. 2022 Oct;102(4):780-797. doi: 10.1016/j.kint.2022.06.026.Epub 2022 Aug 4.
08.12.2022
Maren Gesper
Xue et al. (2022)
“Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and
Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease.”
Circ Res. 2022 Aug 19;131(5):404-420. doi: 10.1161/CIRCRESAHA.122.321253.Epub 2022 Jul 27.
2021
21.01.2021
Linsey Peters
Finney et al. (2017)
„EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis.“
Circulation. 2017 Aug 8;136(6):566-582. doi: 10.1161/CIRCULATIONAHA.116.026644. Epub 2017 May 9.
28.01.2021
Maren Gesper
Li et al. (2018)
„Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis.“
Lab Invest. 2019 Mar;99(3):346-357. doi: 10.1038/s41374-018-0091-y. Epub 2018 Aug 1.
18.02.2021
Maria Chiara Arrivas
Frodermann et al. (2019)
„Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells.“
Nat Med. 2019 Nov;25(11):1761-1771. doi: 10.1038/s41591-019-0633-x. Epub 2019 Nov 7.
25.02.2021
Sophie Kathrin Schiestel
Li et al. (2017)
„Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.“
Cell Metab. 2017 Oct 3;26(4):672-685.e4. doi: 10.1016/j.cmet.2017.08.019. Epub 2017 Sep 14.
04.03.2021
Marina Augusto Heuschkel
Allapanet et al. (2020)
„Warfarin Accelerates Medial Arterial Calcification in Humans.”
Arterioscler Thromb Vasc Biol. 2020 May;40(5):1413-1419. doi: 10.1161/ATVBAHA.119.313879. Epub 2020 Feb 13.
11.03.2021
Michaela Lellig
Ji et al. (2019)
„Alarmone Ap4A is elevated by aminoglycosideantibiotics and enhances their bactericidal activity.“
Proc Natl Acad Sci USA. 2019 May 7;116(19):9578-9585. doi: 10.1073/pnas.1822026116. Epub 2019 Apr 19.
18.03.2021
Pascal Mann
Wang et al. (2016)
„Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.”
Cell. 2016 Sep 8;166(6):1512-1525.e12. doi: 10.1016/j.cell.2016.07.026.
24.03.2021
Rogier Veltrop
Ikeda et al. (2020)
„Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium.“
J Am Coll Cardiol. 2021 Mar 2;77(8):1073-1088. doi: 10.1016/j.jacc.2020.12.060.
Zuppinger et al. (2017)
„Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes.”
Eur J Histochem. 2017 Jun 21;61(2):2763. doi: 10.4081/ejh.2017.2763.
08.04.2021
Sai Sahana Sundararaman
Li et al. (2021)
„Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and
subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression.“
Ren Fail. 2021 Dec;43(1):465-476. doi: 10.1080/0886022X.2021.1881554.
15.04.2021
Jonas Heyn
Brestoff et al. (2021)
„Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity.“
Cell Metab. 2021 Feb 2;33(2):270-282.e8. doi: 10.1016/j.cmet.2020.11.008. Epub 2020 Dec 4.
22.04.2021
Sebastian Maxeiner
Shi et al. (2021)
„Neutrophils can promote clotting via FXI and impact clot structure via neutrophil extracellular traps in a distinctive manner in vitro.“
Sci Rep. 2021 Jan 18;11(1):1718. doi: 10.1038/s41598-021-81268-7.
29.04.2021
Shruti Bhargava
Cobb et al. (2021)
„Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and
Apoptosis of Vascular Smooth Muscle Cells.”
Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1339-1357. doi: 10.1161/ATVBAHA.120.315206. Epub 2020 Dec 24.
06.05.2021
Sofia De la Puente Secades
Martinez-Moreno et al. (2017)
„High phosphate induces a pro-inflammatory response by vascular smooth muscle cells and modulation by vitamin D derivatives.”
Clin Sci (Lond). 2017 Jun 28;131(13):1449-1463. doi: 10.1042/CS20160807. Print 2017 Jul 1.
20.05.2021
Valeria Saar-Kovrov
Furmanik et al. (2020)
„Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and
Extracellular Vesicle-Mediated Vascular Calcification.“
Circ Res. 2020 Sep 11;127(7):911-927. doi: 10.1161/CIRCRESAHA.119.316159. Epub 2020 Jun 22.
17.06.2021
Anika Himmelsbach
Gu et al. (2019)
„Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcification.”
Exp Mol Med. 2019 Jul 10;51(7):1-14. doi: 10.1038/s12276-019-0272-9.
24.06.2021
Andrea Bonnin-Marquez
Baba et al. (2020)
„CXCR4-Binding Positron Emission Tomography Tracers Link Monocyte Recruitment and Endothelial Injury in Murine Atherosclerosis.”
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):822-836. doi: 10.1161/ATVBAHA.120.315053. Epub 2020 Dec 17.
19.08.2021
Christian Hemmers
Chung et al. (2019)
„Mitochondrial damage and activation of the STING pathway leads to renal inflammation and fibrosis.“
Cell Metab. 2019 Oct 1;30(4):784-799.e5. doi: 10.1016/j.cmet.2019.08.003. Epub 2019 Aug 29.
26.08.2021
Constance Baaten
Lin et al. (2021)“
Establishment of a Bernard-Soulier syndrome model in zebrafish.”
Haematologica. 2021 Aug 19.doi: 10.3324/haematol.2021.278893
02.09.2021
Dustin Mikolajetz
Yao et al. (2021)
„Shifting osteogenesis in vascular calcification.”
JCI Insight. 2021 May 24;6(10):e143023. doi: 10.1172/jci.insight.143023.
09.09.2021
Federica Cascone
Baldassarre et al. (2021)
“Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications.”
Hepatology. 2021 Mar 12. doi: 10.1002/hep.31798.
16.09.2021
Giulia Ilaria Bagarolo
Lemesle et al. (2020)
„Apolipoprotein Proteomic Profiling for the Prediction of Cardiovascular Death in Patients with Heart Failure.“
Proteomics Clin Appl. 2020 Nov;14(6):e2000035. doi: 10.1002/prca.202000035. Epub 2020 Sep 28.
23.09.2021
Luis Quintana
Xin et al. (2013)
„Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.“
Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619.
30.09.2021
Jane Lauxen
Kim et al. (2017)
“Increased Neutrophil Extracellular Trap Formation in Uremia Is Associated with Chronic Inflammation and Prevalent Coronary Artery Disease.”
J Immunol Res. 2017;2017:8415179. doi: 10.1155/2017/8415179. Epub 2017 Mar 27.
07.10.2021
Julia Wirth
O’Sullivan et al. (2019)
“Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease
With Renal Inflammation and Cardiac Dysfunction”
Front Physiol. 2019 Nov 15;10:1365. doi: 10.3389/fphys.2019.01365. eCollection 2019.
14.10.2021
Hoda Alibiglou
Petsophonsakul et al. (2021)
"Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular
vesicle release in vascular smooth muscle cells"
Cardiovasc Res. 2021 Jul 17;cvab244. doi: 10.1093/cvr/cvab244. Online ahead of print.
21.10.2021
Linsey Peters
Yadati et al. (2021)
“Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammation in NASH Mice.”
Front Immunol. 2021 Jul 16;12:675535. doi: 10.3389/fimmu.2021.675535. eCollection 2021.
28.10.2021
Maren Gesper
Shil et al. (2021)
“Artificial Sweeteners Negatively Regulate Pathogenic Characteristics of Two Model Gut Bacteria, E. coli and E. faecalis.”
Int J Mol Sci. 2021 May 15;22(10):5228. doi: 10.3390/ijms22105228.
04.11.2021
Marina Augusto Heuschkel
Jaiswal et al. (2017)
“Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.”
N Engl J Med. 2017 Jul 13;377(2):111-121. doi: 10.1056/NEJMoa1701719. Epub 2017 Jun 21.
11.11.2021
Maria Chiara Arrivas
Barrett et al. (2021)
“Chronic stress primes innate immune responses in mice and humans.”
Cell Rep. 2021. PMID: 34496250
18.11.2021
Maximilian Sausen
He et al. (2019)
“Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.”
Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30.
25.11.2021
Michaela Lellig
Zhang et al. (2021)
“Effects of Angiotensin II type I receptor shRNA on blood pressure and left ventricular remodeling in spontaneously hypertensive rats.”
Exp Anim. 2021 Aug 6;70(3):293-301. doi: 10.1538/expanim.20-0152. Epub 2021 Feb 11.
02.12.2021
Nadim Tabaza
Anzai et al. (2017)
“The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.”
J Exp Med. 2017 Nov 6;214(11):3293-3310. doi: 10.1084/jem.20170689. Epub 2017 Oct 4
09.12.2021
Nicolas Hense
Chattopadhyay et al. (2021)
“Cholesterol-Induced Phenotypic Modulation of Smooth Muscle Cells to Macrophage/Fibroblast-like Cells Is Driven by an Unfolded Protein Response.”
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):302-316. doi: 10.1161/ATVBAHA.120.315164. Epub 2020 Oct 8.
16.12.2021
Pascal Mann
Croteau et al. (2021)
“Effects of Sodium-Glucose Linked Transporter 2 Inhibition With Ertugliflozin
on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice.”
J Am Heart Assoc. 2021 Jul 6;10(13):e019995. doi: 10.1161/JAHA.120.019995. Epub 2021 Jun 25.
2020
16.01.2020
Josefin Soppert
Pouwer et al. (2020)
“Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice.”
J Lipid Res. 2020 Mar;61(3):365-375. doi: 10.1194/jlr.RA119000419. Epub 2019 Dec 16.
23.01.2020
Pascal Mann
Ho et al. (2019)
“Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.”
Cardiovasc Res. 2019 Sep 1;115(11):1606-1616. doi: 10.1093/cvr/cvz045.
30.01.2020
Julia Wirth
Jiang et a. (2019)
“Endothelial cell modulation of cardiomyocyte gene expression.”
Exp Cell Res. 2019 Oct 15;383(2):111565. doi: 10.1016/j.yexcr.2019.111565. Epub 2019 Aug 20.
13.02.2020
Kabita Pradhan
Zhao et al. (2018)
“Cardiomyocyte Derived miR-328 Promotes Cardiac Fibrosis by Paracrinely Regulating Adjacent Fibroblasts.”
Cell Physiol Biochem. 2018;46(4):1555-1565. doi: 10.1159/000489201. Epub 2018 Apr 19.
27.02.2020
Katja Krüger
Oleinik et al. (2019)
“Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress.”
Sci Adv. 2019 Sep 11;5(9):eaax1978. doi: 10.1126/sciadv.aax1978. eCollection 2019 Sep.
05.03.2020
Linsey Peters
Negishi et al. (2008)
“A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.”
Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20446-51. doi: 10.1073/pnas.0810372105. Epub 2008 Dec 11
07.05.2020
Mareike Staudt
Rosshart et al. (2019)
"Laboratory mice born to wild mice have natural microbiota and model human immune responses.”
Science. 2019 Aug 2;365(6452):eaaw4361. doi: 10.1126/science.aaw4361. Epub 2019 Aug 1.
14.05.2020
Marina Augusto Heuschkel
Zhang et al. (2020)
“Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals.”
Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):751-765. doi: 10.1161/ATVBAHA.119.313414. Epub 2020 Jan 16.
28.05.2020
Maria Chiara Arrivas
McAlpine et al. (2019)
“Sleep modulates haematopoiesis and protects against atherosclerosis.”
Nature. 2019 Feb;566(7744):383-387. doi: 10.1038/s41586-019-0948-2. Epub 2019 Feb 13.
04.06.2020
Maren Gesper
Tang et al. (2019)
“Loss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair.”
Circulation. 2019 Jan 29;139(5):647-659. doi: 10.1161/CIRCULATIONAHA.118.035235.
18.06.2020
Pascal Mann
Kim et al. (2020)
“SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease.”
Nat Commun. 2020 May 1;11(1):2127. doi: 10.1038/s41467-020-15983-6.
13.08.2020
Sofia de la Puente Secades
De Maré et al. (2019)
„Sclerostin as Regulatory Molecule in Vascular Media Calcification and the Bone–Vascular Axis.“
Toxins (Basel). 2019 Jul 21;11(7):428. doi: 10.3390/toxins11070428.
20.08.2020
Sebastian Maxeiner
Wilbs et al. (2020)
„Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs.“
Nat Commun. 2020 Aug 4;11(1):3890. doi: 10.1038/s41467-020-17648-w.
27.08.2020
Shruti Bhargava
Lino et al. (2018)
„Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1
via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis.“
Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1878-1889. doi: 10.1161/ATVBAHA.118.311238.
03.09.2020
Sai Sahana Sundararaman
Li et al. (2020)
„A novel function of calcium sensing receptor in chronic hypoxia- induced pulmonary venous smooth muscle cells proliferation.“
Hypertens Res. 2020 Apr;43(4):271-280. doi: 10.1038/s41440-019-0373-9. Epub 2019 Dec 18.
24.09.2020
Andrea Bonnin Marquez
Gao et al. (2020)
„Treatment of atherosclerosis by macrophage- biomimetic nanoparticles via targeted
pharmacotherapy and sequestration of proinflammatory cytokines.“
Nat Commun. 2020 May 26;11(1):2622. doi: 10.1038/s41467-020-16439-7.
15.10.2020
Andrea Himmelsbach
Zhou et al. (2020)
„HDAC1-mediated deacetylation of LSD1 regulates vascular calcification by promoting autophagy in chronic renal failure.“
J Cell Mol Med. 2020 Aug;24(15):8636-8649. doi: 10.1111/jcmm.15494. Epub 2020 Jun 28.
22.10.2020
Christian Hemmers
Aubdool et al. (2017)
„A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage
in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure.“
Circulation. 2017 Jul 25;136(4):367-383. doi: 10.1161/CIRCULATIONAHA.117.028388. Epub 2017 Apr 26.
29.10.2020
Dustin Mikolajetz
Pustlauk et al. (2020)
„Induced osteogenic differentiation of human smooth muscle cells as a model of vascular calcification.“
Sci Rep. 2020 Apr 6;10(1):5951. doi: 10.1038/s41598-020-62568-w.
05.11.2020
Constance Baaten
Makhloufi et al. (2020)
„Assessment of Thrombotic and Bleeding Tendency in Two Mouse Models of Chronic Kidney Disease:
Adenine-Diet and 5/6th Nephrectomy.“
TH Open. 2020 Apr 16;4(2):e66-e76. doi: 10.1055/s-0040-1705138. eCollection 2020 Apr.
12.11.2020
Giulia Ilaria Bagarolo
Huebner et al. (2018)
„A Contemporary Conceptual Framework for Initial Data Analysis.”
Observational Studies 4 (2018) 171-192
19.11.2020
Hoda Alibiglou
Gao et al. (2020)
„TNAP inhibition attenuates cardiacfibrosis inducedby myocardial infarction through
deactivating TGF-β1/Smads and activating P53 signaling pathways.“
Int J Mol Sci. 2020 Mar 14;21(6):1994. doi: 10.3390/ijms21061994.
26.11.2020
Katja Krüger
Kahveci et al. (2020)
„Oxidative Stress and Mitochondrial AbnormalitiesContribute to Decreased Endothelial Nitric OxideSynthase Expression
and Renal Disease Progressionin Early Experimental Polycystic Kidney Disease.“
Int J Mol Sci. 2020 Mar 14;21(6):1994. doi: 10.3390/ijms21061994.
17.12.2020
Julia Wirth
Diwan et al. (2014)
„Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats.“
Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1169-78. doi: 10.1152/ajprenal.00676.2013. Epub 2014 Sep 10.
2019
10.01.2019
Shruti Bhargava
Hortells et al. (2015)
“Critical Parameters of the In Vitro Method of Vascular Smooth Muscle Cell Calcification.”
PLoS One. 2015 Nov 10;10(11):e0141751. doi: 10.1371/journal.pone.0141751. eCollection 2015.
14.02.2019
Bilal Mir
Sun et al. (2018)
“TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells.”
Exp Cell Res. 2018 Sep 15;370(2):478-489. doi: 10.1016/j.yexcr.2018.07.013. Epub 2018 Jul 7.
21.02.2019
Anika Himmelsbach
Sun et al. (2012)
“Suppression of Klotho expression by protein-bound uremic toxins is associated with
increased DNA methyltransferase expression and DNA hypermethylation.”
Kidney Int. 2012 Apr;81(7):640-50. doi: 10.1038/ki.2011.445. Epub 2012 Jan 11.
07.03.2019
Caroline Fabian
Kukida et al. (2019)
“AT2 receptor stimulation inhibits phosphate- induced vascular calcification.”
Kidney Int. 2019 Jan;95(1):138-148. doi: 10.1016/j.kint.2018.07.028. Epub 2018 Nov 12.
14.03.2019
Constance Baaten
Guo et al. (2016)
“Impact of renal impairment on platelet reactivity and clinical outcomes during chronic dual antiplatelet therapy following coronary stenting.”
Eur Heart J Cardiovasc Pharmacother. 2016 Jul;2(3):145-51. doi: 10.1093/ehjcvp/pvv052. Epub 2015 Dec 17.
28.03.2019
Julia Möllmann
Byrene et al. (2017)
“Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure.”
JACC Basic Transl Sci. 2017 Aug 4;2(4):347-354. doi: 10.1016/j.jacbts.2017.07.003. eCollection 2017 Aug.
04.04.2019
Giulia Ilaria Bagarolo
Amrhein et al. (2019)
“Scientists rise up against statistical significance.”
Nature. 2019 Mar;567(7748):305-307. doi: 10.1038/d41586-019-00857-9.
11.04.2019
Jana Holmar
Willy et al. (2017)
“Expanded Haemodialysis Therapy of Chronic Haemodialysis Patients Prevents Calcification
and Apoptosis of Vascular Smooth Muscle Cells in vitro.”
Blood Purif. 2018;45(1-3):131-138. doi: 10.1159/000484925. Epub 2017 Dec 22.
18.04.2019
Hoda Alibiglou
Jun Ma et al. (2016)
“Bioabsorbable zinc ion induced biphasic cellular responses in vascular smooth muscle cells.”
Sci Rep. 2016 Jun 1;6:26661. doi: 10.1038/srep26661.
25.04.2019
Miram Ommer
Slawik et al. (2018)
“Irregular pacing of ventricular cardiomyocytes induces pro-fibrotic signalling involving paracrine
effects of transforming growth factor beta and connective tissue growth factor.”
Eur J Heart Fail. 2019 Apr;21(4):482-491. doi: 10.1002/ejhf.1392. Epub 2019 Jan 24.
02.05.2019
Katja Krüger
Kieswich et al. (2018)
“A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain.”
BMC Nephrol. 2018 Dec 4;19(1):346. doi: 10.1186/s12882-018-1155-3.
09.05.2019
Eva Harlacher
Belmokhtar et al. (2016)
“Signaling of Serum Amyloid A Through Receptor for Advanced Glycation End Products
as a Possible Mechanism for Uremia-Related Atherosclerosis.”
Arterioscler Thromb Vasc Biol. 2016 May;36(5):800-9. doi: 10.1161/ATVBAHA.115.306349. Epub 2016 Mar 17.
16.05.2019
Julia Wirth
Leifheit- Nestler et al. (2018)
“Fibroblast growth factor 23 is induced by an activated renin-angiotensin-aldosterone system in
cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts.”
Nephrol Dial Transplant. 2018 Oct 1;33(10):1722-1734. doi: 10.1093/ndt/gfy006.
23.05.2019
Mareike Staudt
Ketszeri et al. (2019)
“MicroRNA-142-3p improves vascular relaxation in uremia.”
Atherosclerosis. 2019 Jan;280:28-36. doi: 10.1016/j.atherosclerosis.2018.11.024. Epub 2018 Nov 10.
06.06.2019
Maren Gesper
Nishiyama et al. (2019)
“Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility.”
J Cell Physiol. 2019 May;234(5):6667-6678. doi: 10.1002/jcp.27408. Epub 2018 Oct 14.
13.06.2019
Marieke Sternkopf
Gupta et al. (2012)
“Sitagliptin: Anti-platelet effect in diabetes and healthy volunteers.”
Platelets. 2012;23(8):565-70. doi: 10.3109/09537104.2012.721907. Epub 2012 Sep 5.
27.06.2019
Marina Augusto Heuschkel
Huang et al. (2019)
“SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.”
Nature. 2019 May;569(7757):565-569. doi: 10.1038/s41586-019-1140-4. Epub 2019 Apr 24.
11.07.2019
Pascal Mann
Osataphan et al. (2019)
“SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and - independent mechanisms.”
JCI Insight. 2019 Mar 7;4(5):e123130. doi: 10.1172/jci.insight.123130.
05.09.2019
Sofia de la Puente Secades
Ruisgang et al. (2017)
„Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype
of Interstitial Cells in Calcified Human Aortic Valves.“
J Am Heart Assoc. 2017 Apr 24;6(4):e005364. doi: 10.1161/JAHA.116.005364.
12.09.2019
Sebastian Maxeiner
Kearney et al. (2019)
„Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications.“
Blood. 2019 Mar 14;133(11):1233-1244. doi: 10.1182/blood-2018-06-856195. Epub 2018 Dec 13.
19.09.2019
Shruti Bhargava
Applebaum et al. (2014)
„Segregation of striated and smooth muscle lineages by a Notch-dependent regulatory network.”
BMC Biol. 2014 Jul 12;12:53. doi: 10.1186/s12915-014-0053-9.
26.09.2019
Rogier Veltrop
Shah et al. (2019)
„Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells.”
Cells. 2019 Jun 15;8(6):594. doi: 10.3390/cells8060594.
10.10.2019
Valeria Saar-Kovrov
Hu et al. (2019)
„Cyanate Induces Oxidative Stress Injury and Abnormal Lipid Metabolism in Liver through Nrf2/HO-1.”
Molecules. 2019 Sep 5;24(18):3231. doi: 10.3390/molecules24183231.
17.10.2019
Balram Neupane
Beyret et al. (2019)
„Single-dose CRISPR–Cas9 therapy extends lifespan of mice with Hutchinson–Gilford progeria syndrome.“
Nat Med. 2019 Mar;25(3):419-422. doi: 10.1038/s41591-019-0343-4. Epub 2019 Feb 18.
24.10.2019
Christian Hemmers
Landry et al. (2018)
„Ski drives an acute increase in MMP-9 gene expression and release in primary cardiac myofibroblasts.“
Physiol Rep. 2018 Nov;6(22):e13897. doi: 10.14814/phy2.13897.
31.10.2019
Bilal Mir
Kapustin et al. (2015)
„Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion.“
Circ Res. 2015 Apr 10;116(8):1312-23. doi: 10.1161/CIRCRESAHA.116.305012. Epub 2015 Feb 23.
07.11.2019
Caroline Fabian
Sanchis et al. (2019)
„Arterial “inflammaging” drives vascular calcification in children on dialysis.”
Kidney Int. 2019 Apr;95(4):958-972. doi: 10.1016/j.kint.2018.12.014. Epub 2019 Mar 1.
14.11.2019
Anika Himmelsbach
Zhu et al. (2016)
“A novel role for the mineralocorticoid receptor in glucocorticoid driven vascular calcification.”
Vascul Pharmacol. 2016 Nov;86:87-93.doi: 10.1016/j.vph.2016.04.005. Epub 2016 May 3.
Tatsumoto et al. (2015)
“Spironolactone ameliorates arterial medial calcification in uremic rats:
the role of mineralocorticoid receptor signaling in vascular calcification.”
Am J Physiol Renal Physiol. 2015 Dec 1;309(11):F967-79. doi: 10.1152/ajprenal.00669.2014. Epub 2015 Sep 2
21.11.2019
Constance Baaten
Zhu et al. (2016)
“Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk”
Cell. 2016 Mar 24;165(1):111-124. doi: 10.1016/j.cell.2016.02.011. Epub 2016 Mar 10.
28.11.2019
Eva Harlacher
Winterberg et al. (2019)
“T Cells Play a Causal Role in Diastolic Dysfunction during Uremic Cardiomyopathy.”
J Am Soc Nephrol. 2019 Feb 6;30(3):407-420. doi: 10.1681/ASN.2017101138. Online ahead of print.
12.12.2019
Guzide Bender
Fotakis et al. (2019)
“Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate
Over Proinflammatory Effects in Atherosclerotic Plaques.”
Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):e253-e272. doi: 10.1161/ATVBAHA.119.313253. Epub 2019 Oct 3.
19.12.2019
Hoda Alibiglou
Tziakas et al. (2019)
“Lysed Erythrocyte Membranes Promote Vascular Calcification.”
Circulation. 2019 Apr 23;139(17):2032-2048. doi: 10.1161/CIRCULATIONAHA.118.037166.
2018
14.05.2018
Astrid Artmeyer
Emmens at al. (2017)
„Proteomic diversity of high-density lipoprotein explains its association with clinical outcome in patients with heart failure.“
Eur J Heart Fail. 2018 Feb;20(2):260-267. doi: 10.1002/ejhf.1101. Epub 2017 Dec 18.
24.05.2018
Anika Himmelsbach
Tsai et al. (2017)
„Anomalous baroreflex functionality inherent in floxed and Cre-Lox mice: an overlooked physiological phenotype.“
Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H700-H707. doi: 10.1152/ajpheart.00346.2017. Epub 2017 Aug 4.
Zomer at al. (2015)
„In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior.”
Cell. 2015 May 21;161(5):1046-1057. doi: 10.1016/j.cell.2015.04.042.
07.06.2018
Bilal Mir
Camargo et al. (2018)
“Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation,
and Endoplasmic Reticulum Stress Response in Hypertension.”
Hypertension. 2018 Jul;72(1):235-246. doi: 10.1161/HYPERTENSIONAHA.118.10824. Epub 2018 May 29.
21.06.2018
Christian Hemmers
Brinck et al. (2018)
“High-density lipoprotein from end-stage renal disease patients exhibits superior
cardioprotection and increase in sphingosine-1- phosphate.”
Eur J Clin Invest. 2018 Feb;48(2). doi: 10.1111/eci.12866. Epub 2017 Dec 14.
16.08.2018
Corinna Schulte
Wang et al. (2007)
“Protein carbamylation links inflammation, smoking, uremia and atherogenesis.”
Nat Med. 2007 Oct;13(10):1176-84. doi: 10.1038/nm1637. Epub 2007 Sep 9.
30.08.2018
Eva Harlacher
Saum et al. (2018)
“Uremic Advanced Glycation End Products and Protein-Bound Solutes Induce Endothelial
Dysfunction Through Suppression of Krüppel-Like Factor 2.”
J Am Heart Assoc. 2018 Jan 4;7(1): e007566. doi: 10.1161/JAHA.117.007566.
13.09.2018
Jana Holmar
Frauscher at al. (2018)
“Autophagy Protects From Uremic Vascular Media calcification.”
Front Immunol. 2018 Aug 14;9:1866. Doi: 10.3389/fimmu.2018.01866. eCollection 2018.
20.09.2018
Josefin Soppert
Feng et al. (2017)
“Advanced oxidation protein products aggravate cardiac remodeling via cardiomyocyte apoptosis in chronic kidney disease”
Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H475-H483. Doi: 10.1152/ajpheart.00628.2016. Epub 2017 Nov 3.
04.10.2018
Katja Krüger
Wang et al. (2018)
“Dietary supplementation with ketoacids protects against CKD-induced oxidative damage and
mitochondrial dysfunction in skeletal muscle of 5/6 nephrectomised rats.”
Skelet Muscle. 2018 May 31;8(1):18. Doi: 10.1186/s13395-018-0164-z.
11.10.2018
Julia Wirth
Yang et al. (2015)
“Indoxyl sulfate induces oxidative stress and hypertrophy in cardiomyocytes by inhibiting the AMPK/UCP2 signaling pathway.”
Toxicol Lett. 2015 Apr 16;234(2):110-9. Doi: 10.1016/j.toxlet.2015.01.021. Epub 2015 Feb 19.
08.11.2018
Maren Gesper
Suez et al. (2014)
“Artificial sweeteners induce glucose intolerance by altering the gut microbiota.”
Nature. 2014 Oct 9;514(7521):181-6. Doi: 10.1038/nature13793. Epub 2014 Sep 17.
15.11.2018
Mareike Staudt
Shang et al. (2017)
“MicroRNA-92a mediates endothelial dysfunction in CKD.”
Am Soc Nephrol. 2017 Nov;28(11):3251-3261. Doi: 10.1681/ASN.2016111215. Epub 2017 Jul 10.
22.11.2018
Marina Augusto Heuschkel
Hamczyk et al. (2018)
“Vascular Smooth Muscle–Specific Progerin Expression Accelerates Atherosclerosis and
Death in a Mouse Model of Hutchinson- Gilford Progeria Syndrome.”
Circulation. 2018 Jul 17;138(3):266-282. Doi: 10.1161/CIRCULATIONAHA.117.030856. Epub 2018 Feb 28.
06.12.2018
Mihaela Rusu
Asgari et al. (2017)
“In vitro fibrillogenesis of tropocollagen type III in collagen type I affects its relative fibrillar topology and mechanics.”
Sci Rep. 2017 May 3;7(1):1392. doi: 10.1038/s41598-017-01476-y.
13.12.2018
Pascal Mann
Temple et al. (2018)
“Fat, Sugar, Whole Grains and Heart Disease: 50 Years of Confusion.”
Nutrients. 2018 Jan 4;10(1):39. doi: 10.3390/nu10010039.
20.12.2018
Sebastian Maxeiner
Tian et al. (2013)
“High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.”
Nature. 2013 Jul 18;499(7458):346-9. doi: 10.1038/nature12234. Epub 2013 Jun 19.
Ruby et al. (2018)
“Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age.”
Elife. 2018 Jan 24;7:e31157. doi: 10.7554/eLife.31157.
Park et al. (2017)
“Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.”
Science. 2017 Apr 21;356(6335):307-311. doi: 10.1126/science.aab3896.
.