IRTG Journal Club



Linsey Peters

"EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis."

Circulation. 2017 Aug 8;136(6):566-582. doi: 10.1161/CIRCULATIONAHA.116.026644. Epub 2017 May 9.



Maren Gesper

"Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis.“

Lab Invest. 2019 Mar;99(3):346-357. doi: 10.1038/s41374-018-0091-y. Epub 2018 Aug 1.



Maria Chiara Arrivas

"Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells.“

Nat Med. 2019 Nov;25(11):1761-1771. doi: 10.1038/s41591-019-0633-x. Epub 2019 Nov 7.



Sophie Kathrin Schiestel

"Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.“

Cell Metab. 2017 Oct 3;26(4):672-685.e4. doi: 10.1016/j.cmet.2017.08.019. Epub 2017 Sep 14.



Marina Augusto Heuschkel

"Warfarin Accelerates Medial Arterial Calcification in Humans.”

Arterioscler Thromb Vasc Biol. 2020 May;40(5):1413-1419. doi: 10.1161/ATVBAHA.119.313879. Epub 2020 Feb 13.



Michaela Lellig

"Alarmone Ap4A is elevated by aminoglycosideantibiotics and enhances their bactericidal activity.“

Proc Natl Acad Sci USA. 2019 May 7;116(19):9578-9585. doi: 10.1073/pnas.1822026116. Epub 2019 Apr 19.



Pascal Mann

"Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.

Cell. 2016 Sep 8;166(6):1512-1525.e12. doi: 10.1016/j.cell.2016.07.026.


Rogier Veltrop

Ikeda et al. (2020)

„Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium.“

J Am Coll Cardiol. 2021 Mar 2;77(8):1073-1088. doi: 10.1016/j.jacc.2020.12.060.


Zuppinger et al. (2017)

„Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes.”

Eur J Histochem. 2017 Jun 21;61(2):2763. doi: 10.4081/ejh.2017.2763.



Sai Sahana Sundararaman

Li et al. (2021)

„Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression.“

Ren Fail. 2021 Dec;43(1):465-476. doi: 10.1080/0886022X.2021.1881554.



Jonas Heyn

Brestoff et al. (2021)

„Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity.“

Cell Metab. 2021 Feb 2;33(2):270-282.e8. doi: 10.1016/j.cmet.2020.11.008. Epub 2020 Dec 4.



Sebastian Maxeiner

Shi et al. (2021)

„Neutrophils can promote clotting via FXI and impact clot structure via neutrophil extracellular traps in a distinctive manner in vitro.“

Sci Rep. 2021 Jan 18;11(1):1718. doi: 10.1038/s41598-021-81268-7.



Shruti Bhargava

Cobb et al. (2021)

„Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis of Vascular Smooth Muscle Cells.”

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1339-1357. doi: 10.1161/ATVBAHA.120.315206. Epub 2020 Dec 24.



Sofia De la Puente Secades

Martinez-Moreno et al. (2017)

„High phosphate induces a pro-inflammatory response by vascular smooth muscle cells and modulation by vitamin D derivatives.”

Clin Sci (Lond). 2017 Jun 28;131(13):1449-1463. doi: 10.1042/CS20160807. Print 2017 Jul 1.



Valeria Saar-Kovrov

Furmanik et al. (2020)

„Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification.“

Circ Res. 2020 Sep 11;127(7):911-927. doi: 10.1161/CIRCRESAHA.119.316159. Epub 2020 Jun 22.



Anika Himmelsbach

Gu et al. (2019)

„Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcification.”

Exp Mol Med. 2019 Jul 10;51(7):1-14. doi: 10.1038/s12276-019-0272-9.



Josefin Soppert

Pouwer et al. (2020)

“Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice.”

J Lipid Res. 2020 Mar;61(3):365-375. doi: 10.1194/jlr.RA119000419. Epub 2019 Dec 16.



Pascal Mann

Ho et al. (2019)

“Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.”

Cardiovasc Res. 2019 Sep 1;115(11):1606-1616. doi: 10.1093/cvr/cvz045.



Julia Wirth

Jiang et a. (2019)

“Endothelial cell modulation of cardiomyocyte gene expression.”

Exp Cell Res. 2019 Oct 15;383(2):111565. doi: 10.1016/j.yexcr.2019.111565. Epub 2019 Aug 20.



Kabita Pradhan

Zhao et al. (2018)

“Cardiomyocyte Derived miR-328 Promotes Cardiac Fibrosis by Paracrinely Regulating Adjacent Fibroblasts.”

Cell Physiol Biochem. 2018;46(4):1555-1565. doi: 10.1159/000489201. Epub 2018 Apr 19.



Katja Krüger

Oleinik et al. (2019)

“Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress.”

Sci Adv. 2019 Sep 11;5(9):eaax1978. doi: 10.1126/sciadv.aax1978. eCollection 2019 Sep.



Linsey Peters

Negishi et al. (2008)

“A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.”

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20446-51. doi: 10.1073/pnas.0810372105. Epub 2008 Dec 11



Mareike Staudt

Rosshart et al. (2019)

"Laboratory mice born to wild mice have natural microbiota and model human immune responses.”

Science. 2019 Aug 2;365(6452):eaaw4361. doi: 10.1126/science.aaw4361. Epub 2019 Aug 1.



Marina Augusto Heuschkel

Zhang et al. (2020)

“Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals.”

Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):751-765. doi: 10.1161/ATVBAHA.119.313414. Epub 2020 Jan 16.



Maria Chiara Arrivas

McAlpine et al. (2019)

“Sleep modulates haematopoiesis and protects against atherosclerosis.”

Nature. 2019 Feb;566(7744):383-387. doi: 10.1038/s41586-019-0948-2. Epub 2019 Feb 13.



Maren Gesper

Tang et al. (2019)

“Loss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair.”

Circulation. 2019 Jan 29;139(5):647-659. doi: 10.1161/CIRCULATIONAHA.118.035235.



Pascal Mann

Kim et al. (2020)

“SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease.”

Nat Commun. 2020 May 1;11(1):2127. doi: 10.1038/s41467-020-15983-6.



Sofia de la Puente Secades

De Maré et al. (2019)

„Sclerostin as Regulatory Molecule in Vascular Media Calcification and the Bone–Vascular Axis.“

Toxins (Basel). 2019 Jul 21;11(7):428. doi: 10.3390/toxins11070428.



Sebastian Maxeiner

Wilbs et al. (2020)

„Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs.“

Nat Commun. 2020 Aug 4;11(1):3890. doi: 10.1038/s41467-020-17648-w.



Shruti Bhargava

Lino et al. (2018)

„Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1

via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis.“

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1878-1889. doi: 10.1161/ATVBAHA.118.311238.



Sai Sahana Sundararaman

Li et al. (2020)

„A novel function of calcium sensing receptor in chronic hypoxia- induced pulmonary venous smooth muscle cells proliferation.“

Hypertens Res. 2020 Apr;43(4):271-280. doi: 10.1038/s41440-019-0373-9. Epub 2019 Dec 18.



Andrea Bonnin Marquez

Gao et al. (2020)

„Treatment of atherosclerosis by macrophage- biomimetic nanoparticles via targeted

pharmacotherapy and sequestration of proinflammatory cytokines.“

Nat Commun. 2020 May 26;11(1):2622. doi: 10.1038/s41467-020-16439-7.



Andrea Himmelsbach

Zhou et al. (2020)

„HDAC1-mediated deacetylation of LSD1 regulates vascular calcification by promoting autophagy in chronic renal failure.“

J Cell Mol Med. 2020 Aug;24(15):8636-8649. doi: 10.1111/jcmm.15494. Epub 2020 Jun 28.



Christian Hemmers

Aubdool et al. (2017)

„A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage

in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure.“

Circulation. 2017 Jul 25;136(4):367-383. doi: 10.1161/CIRCULATIONAHA.117.028388. Epub 2017 Apr 26.



Dustin Mikolajetz

Pustlauk et al. (2020)

„Induced osteogenic differentiation of human smooth muscle cells as a model of vascular calcification.“

Sci Rep. 2020 Apr 6;10(1):5951. doi: 10.1038/s41598-020-62568-w.



Constance Baaten

Makhloufi et al. (2020)

„Assessment of Thrombotic and Bleeding Tendency in Two Mouse Models of Chronic Kidney Disease:

Adenine-Diet and 5/6th Nephrectomy.“

TH Open. 2020 Apr 16;4(2):e66-e76. doi: 10.1055/s-0040-1705138. eCollection 2020 Apr.



Giulia Ilaria Bagarolo

Huebner et al. (2018)

„A Contemporary Conceptual Framework for Initial Data Analysis.”

Observational Studies 4 (2018) 171-192



Hoda Alibiglou

Gao et al. (2020)

„TNAP inhibition attenuates cardiacfibrosis inducedby myocardial infarction through

deactivating TGF-β1/Smads and activating P53 signaling pathways.“

Int J Mol Sci. 2020 Mar 14;21(6):1994. doi: 10.3390/ijms21061994.



Katja Krüger

Kahveci et al. (2020)

„Oxidative Stress and Mitochondrial AbnormalitiesContribute to Decreased Endothelial Nitric OxideSynthase Expression

and Renal Disease Progressionin Early Experimental Polycystic Kidney Disease.“

Int J Mol Sci. 2020 Mar 14;21(6):1994. doi: 10.3390/ijms21061994.



Julia Wirth

Diwan et al. (2014)

„Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats.“

Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1169-78. doi: 10.1152/ajprenal.00676.2013. Epub 2014 Sep 10.






Shruti Bhargava

Hortells et al. (2015)

“Critical Parameters of the In Vitro Method of Vascular Smooth Muscle Cell Calcification.”

PLoS One. 2015 Nov 10;10(11):e0141751. doi: 10.1371/journal.pone.0141751. eCollection 2015.



Bilal Mir

Sun et al. (2018)

“TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells.”

Exp Cell Res. 2018 Sep 15;370(2):478-489. doi: 10.1016/j.yexcr.2018.07.013. Epub 2018 Jul 7.



Anika Himmelsbach

Sun et al. (2012)

“Suppression of Klotho expression by protein-bound uremic toxins is associated with

increased DNA methyltransferase expression and DNA hypermethylation.”

Kidney Int. 2012 Apr;81(7):640-50. doi: 10.1038/ki.2011.445. Epub 2012 Jan 11.



Caroline Fabian

Kukida et al. (2019)

“AT2 receptor stimulation inhibits phosphate- induced vascular calcification.”

Kidney Int. 2019 Jan;95(1):138-148. doi: 10.1016/j.kint.2018.07.028. Epub 2018 Nov 12.



Constance Baaten

Guo et al. (2016)

“Impact of renal impairment on platelet reactivity and clinical outcomes during chronic dual antiplatelet therapy following coronary stenting.”

Eur Heart J Cardiovasc Pharmacother. 2016 Jul;2(3):145-51. doi: 10.1093/ehjcvp/pvv052. Epub 2015 Dec 17.



Julia Möllmann

Byrene et al. (2017)

“Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure.”

JACC Basic Transl Sci. 2017 Aug 4;2(4):347-354. doi: 10.1016/j.jacbts.2017.07.003. eCollection 2017 Aug.



Giulia Ilaria Bagarolo

Amrhein et al. (2019)

“Scientists rise up against statistical significance.”

Nature. 2019 Mar;567(7748):305-307. doi: 10.1038/d41586-019-00857-9.



Jana Holmar

Willy et al. (2017)

“Expanded Haemodialysis Therapy of Chronic Haemodialysis Patients Prevents Calcification

and Apoptosis of Vascular Smooth Muscle Cells in vitro.”

Blood Purif. 2018;45(1-3):131-138. doi: 10.1159/000484925. Epub 2017 Dec 22.



Hoda Alibiglou

Jun Ma et al. (2016)

“Bioabsorbable zinc ion induced biphasic cellular responses in vascular smooth muscle cells.”

Sci Rep. 2016 Jun 1;6:26661. doi: 10.1038/srep26661.



Miram Ommer

Slawik et al. (2018)

“Irregular pacing of ventricular cardiomyocytes induces pro-fibrotic signalling involving paracrine

effects of transforming growth factor beta and connective tissue growth factor.”

Eur J Heart Fail. 2019 Apr;21(4):482-491. doi: 10.1002/ejhf.1392. Epub 2019 Jan 24.



Katja Krüger

Kieswich et al. (2018)

“A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain.”

BMC Nephrol. 2018 Dec 4;19(1):346. doi: 10.1186/s12882-018-1155-3.



Eva Harlacher

Belmokhtar et al. (2016)

“Signaling of Serum Amyloid A Through Receptor for Advanced Glycation End Products

as a Possible Mechanism for Uremia-Related Atherosclerosis.”

Arterioscler Thromb Vasc Biol. 2016 May;36(5):800-9. doi: 10.1161/ATVBAHA.115.306349. Epub 2016 Mar 17.



Julia Wirth

Leifheit- Nestler et al. (2018)

“Fibroblast growth factor 23 is induced by an activated renin-angiotensin-aldosterone system in

cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts.”

Nephrol Dial Transplant. 2018 Oct 1;33(10):1722-1734. doi: 10.1093/ndt/gfy006.



Mareike Staudt

Ketszeri et al. (2019)

“MicroRNA-142-3p improves vascular relaxation in uremia.”

Atherosclerosis. 2019 Jan;280:28-36. doi: 10.1016/j.atherosclerosis.2018.11.024. Epub 2018 Nov 10.



Maren Gesper

Nishiyama et al. (2019)

“Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility.”

J Cell Physiol. 2019 May;234(5):6667-6678. doi: 10.1002/jcp.27408. Epub 2018 Oct 14.



Marieke Sternkopf

Gupta et al. (2012)

“Sitagliptin: Anti-platelet effect in diabetes and healthy volunteers.”

Platelets. 2012;23(8):565-70. doi: 10.3109/09537104.2012.721907. Epub 2012 Sep 5.



Marina Augusto Heuschkel

Huang et al. (2019)

“SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.”

Nature. 2019 May;569(7757):565-569. doi: 10.1038/s41586-019-1140-4. Epub 2019 Apr 24.



Pascal Mann

Osataphan et al. (2019)

“SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and - independent mechanisms.”

JCI Insight. 2019 Mar 7;4(5):e123130. doi: 10.1172/jci.insight.123130.



Sofia de la Puente Secades

Ruisgang et al. (2017)

„Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype

of Interstitial Cells in Calcified Human Aortic Valves.“

J Am Heart Assoc. 2017 Apr 24;6(4):e005364. doi: 10.1161/JAHA.116.005364.



Sebastian Maxeiner

Kearney et al. (2019)

„Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications.“

Blood. 2019 Mar 14;133(11):1233-1244. doi: 10.1182/blood-2018-06-856195. Epub 2018 Dec 13.



Shruti Bhargava

Applebaum et al. (2014)

„Segregation of striated and smooth muscle lineages by a Notch-dependent regulatory network.”

BMC Biol. 2014 Jul 12;12:53. doi: 10.1186/s12915-014-0053-9.



Rogier Veltrop

Shah et al. (2019)

„Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells.”

Cells. 2019 Jun 15;8(6):594. doi: 10.3390/cells8060594.



Valeria Saar-Kovrov

Hu et al. (2019)

„Cyanate Induces Oxidative Stress Injury and Abnormal Lipid Metabolism in Liver through Nrf2/HO-1.”

Molecules. 2019 Sep 5;24(18):3231. doi: 10.3390/molecules24183231.



Balram Neupane

Beyret et al. (2019)

„Single-dose CRISPR–Cas9 therapy extends lifespan of mice with Hutchinson–Gilford progeria syndrome.“

Nat Med. 2019 Mar;25(3):419-422. doi: 10.1038/s41591-019-0343-4. Epub 2019 Feb 18.



Christian Hemmers

Landry et al. (2018)

„Ski drives an acute increase in MMP-9 gene expression and release in primary cardiac myofibroblasts.“

Physiol Rep. 2018 Nov;6(22):e13897. doi: 10.14814/phy2.13897.



Bilal Mir

Kapustin et al. (2015)

„Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion.“

Circ Res. 2015 Apr 10;116(8):1312-23. doi: 10.1161/CIRCRESAHA.116.305012. Epub 2015 Feb 23.



Caroline Fabian

Sanchis et al. (2019)

„Arterial “inflammaging” drives vascular calcification in children on dialysis.”

Kidney Int. 2019 Apr;95(4):958-972. doi: 10.1016/j.kint.2018.12.014. Epub 2019 Mar 1.



Anika Himmelsbach

Zhu et al. (2016)

“A novel role for the mineralocorticoid receptor in glucocorticoid driven vascular calcification.”

Vascul Pharmacol. 2016 Nov;86:87-93.doi: 10.1016/j.vph.2016.04.005. Epub 2016 May 3.


Tatsumoto et al. (2015)

“Spironolactone ameliorates arterial medial calcification in uremic rats:

the role of mineralocorticoid receptor signaling in vascular calcification.”

Am J Physiol Renal Physiol. 2015 Dec 1;309(11):F967-79. doi: 10.1152/ajprenal.00669.2014. Epub 2015 Sep 2




Constance Baaten

Zhu et al. (2016)

“Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk”

Cell. 2016 Mar 24;165(1):111-124. doi: 10.1016/j.cell.2016.02.011. Epub 2016 Mar 10.



Eva Harlacher

Winterberg et al. (2019)

“T Cells Play a Causal Role in Diastolic Dysfunction during Uremic Cardiomyopathy.”

J Am Soc Nephrol. 2019 Feb 6;30(3):407-420. doi: 10.1681/ASN.2017101138. Online ahead of print.



Guzide Bender

Fotakis et al. (2019)

“Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate

Over Proinflammatory Effects in Atherosclerotic Plaques.”

Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):e253-e272. doi: 10.1161/ATVBAHA.119.313253. Epub 2019 Oct 3.



Hoda Alibiglou

Tziakas et al. (2019)

“Lysed Erythrocyte Membranes Promote Vascular Calcification.”

Circulation. 2019 Apr 23;139(17):2032-2048. doi: 10.1161/CIRCULATIONAHA.118.037166.







Astrid Artmeyer

Emmens at al. (2017)

„Proteomic diversity of high-density lipoprotein explains its association with clinical outcome in patients with heart failure.“

Eur J Heart Fail. 2018 Feb;20(2):260-267. doi: 10.1002/ejhf.1101. Epub 2017 Dec 18.



Anika Himmelsbach

Tsai et al. (2017)

„Anomalous baroreflex functionality inherent in floxed and Cre-Lox mice: an overlooked physiological phenotype.“

Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H700-H707. doi: 10.1152/ajpheart.00346.2017. Epub 2017 Aug 4.


Zomer at al. (2015)

„In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior.”

Cell. 2015 May 21;161(5):1046-1057. doi: 10.1016/j.cell.2015.04.042.



Bilal Mir

Camargo et al. (2018)

“Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation,

and Endoplasmic Reticulum Stress Response in Hypertension.”

Hypertension. 2018 Jul;72(1):235-246. doi: 10.1161/HYPERTENSIONAHA.118.10824. Epub 2018 May 29.



Christian Hemmers

Brinck et al. (2018)

“High-density lipoprotein from end-stage renal disease patients exhibits superior

cardioprotection and increase in sphingosine-1- phosphate.”

Eur J Clin Invest. 2018 Feb;48(2). doi: 10.1111/eci.12866. Epub 2017 Dec 14.



Corinna Schulte

Wang et al. (2007)

“Protein carbamylation links inflammation, smoking, uremia and atherogenesis.”

Nat Med. 2007 Oct;13(10):1176-84. doi: 10.1038/nm1637. Epub 2007 Sep 9.



Eva Harlacher

Saum et al. (2018)

“Uremic Advanced Glycation End Products and Protein-Bound Solutes Induce Endothelial

Dysfunction Through Suppression of Krüppel-Like Factor 2.”

J Am Heart Assoc. 2018 Jan 4;7(1): e007566. doi: 10.1161/JAHA.117.007566.



Jana Holmar

Frauscher at al. (2018)

“Autophagy Protects From Uremic Vascular Media calcification.”

Front Immunol. 2018 Aug 14;9:1866. Doi: 10.3389/fimmu.2018.01866. eCollection 2018.



Josefin Soppert

Feng et al. (2017)

“Advanced oxidation protein products aggravate cardiac remodeling via cardiomyocyte apoptosis in chronic kidney disease”

Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H475-H483. Doi: 10.1152/ajpheart.00628.2016. Epub 2017 Nov 3.



Katja Krüger

Wang et al. (2018)

“Dietary supplementation with ketoacids protects against CKD-induced oxidative damage and

mitochondrial dysfunction in skeletal muscle of 5/6 nephrectomised rats.”

Skelet Muscle. 2018 May 31;8(1):18. Doi: 10.1186/s13395-018-0164-z.



Julia Wirth

Yang et al. (2015)

“Indoxyl sulfate induces oxidative stress and hypertrophy in cardiomyocytes by inhibiting the AMPK/UCP2 signaling pathway.”

Toxicol Lett. 2015 Apr 16;234(2):110-9. Doi: 10.1016/j.toxlet.2015.01.021. Epub 2015 Feb 19.



Maren Gesper

Suez et al. (2014)

“Artificial sweeteners induce glucose intolerance by altering the gut microbiota.”

Nature. 2014 Oct 9;514(7521):181-6. Doi: 10.1038/nature13793. Epub 2014 Sep 17.



Mareike Staudt

Shang et al. (2017)

“MicroRNA-92a mediates endothelial dysfunction in CKD.”

Am Soc Nephrol. 2017 Nov;28(11):3251-3261. Doi: 10.1681/ASN.2016111215. Epub 2017 Jul 10.



Marina Augusto Heuschkel

Hamczyk et al. (2018)

“Vascular Smooth Muscle–Specific Progerin Expression Accelerates Atherosclerosis and

Death in a Mouse Model of Hutchinson- Gilford Progeria Syndrome.”

Circulation. 2018 Jul 17;138(3):266-282. Doi: 10.1161/CIRCULATIONAHA.117.030856. Epub 2018 Feb 28.



Mihaela Rusu

Asgari et al. (2017)

“In vitro fibrillogenesis of tropocollagen type III in collagen type I affects its relative fibrillar topology and mechanics.”

Sci Rep. 2017 May 3;7(1):1392. doi: 10.1038/s41598-017-01476-y.



Pascal Mann

Temple et al. (2018)

“Fat, Sugar, Whole Grains and Heart Disease: 50 Years of Confusion.”

Nutrients. 2018 Jan 4;10(1):39. doi: 10.3390/nu10010039.



Sebastian Maxeiner

Tian et al. (2013)

“High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.”

Nature. 2013 Jul 18;499(7458):346-9. doi: 10.1038/nature12234. Epub 2013 Jun 19.


Ruby et al. (2018)

“Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age.”

Elife. 2018 Jan 24;7:e31157. doi: 10.7554/eLife.31157.


Park et al. (2017)

“Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.”

Science. 2017 Apr 21;356(6335):307-311. doi: 10.1126/science.aab3896.