PhD MD TRR219-associated students

Hoda Alibiglou

 

PhD student

University Hospital RWTH Aachen

Department of Cardiology, Medical Clinic I

 

Project: Molecular machinery that functionally regulates TNAP activation in calcifying vascular smooth muscle cells

PI: Claudia Goettsch

Microcalcification associates with reduce atherosclerotic plaque integrity and may trigger rupture. Tissue non-specific alkaline phosphatase (TNAP) is a key enzyme in the calcification process. The main objective of this study is to determine the molecular mechanisms that are involved in TNAP maturation and activation.

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