PhD MD TRR219-associated students
University Hospital RWTH Aachen
Department of Cardiology, Medical Clinic I
Project: Molecular machinery that functionally regulates TNAP activation in calcifying vascular smooth muscle cells
PI: Claudia Goettsch
Microcalcification associates with reduce atherosclerotic plaque integrity and may trigger rupture. Tissue non-specific alkaline phosphatase (TNAP) is a key enzyme in the calcification process. The main objective of this study is to determine the molecular mechanisms that are involved in TNAP maturation and activation.